In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2

The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molec...

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Autores principales: Villalobos-Sánchez, Erendira, García-Ruiz, Daniel, Camacho-Villegas, Tanya A., Canales-Aguirre, Alejandro A., Gutiérrez-Ortega, Abel, Muñoz-Medina, José E., Elizondo-Quiroga, Darwin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222355/
https://www.ncbi.nlm.nih.gov/pubmed/37243241
http://dx.doi.org/10.3390/v15051155
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author Villalobos-Sánchez, Erendira
García-Ruiz, Daniel
Camacho-Villegas, Tanya A.
Canales-Aguirre, Alejandro A.
Gutiérrez-Ortega, Abel
Muñoz-Medina, José E.
Elizondo-Quiroga, Darwin E.
author_facet Villalobos-Sánchez, Erendira
García-Ruiz, Daniel
Camacho-Villegas, Tanya A.
Canales-Aguirre, Alejandro A.
Gutiérrez-Ortega, Abel
Muñoz-Medina, José E.
Elizondo-Quiroga, Darwin E.
author_sort Villalobos-Sánchez, Erendira
collection PubMed
description The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2.
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spelling pubmed-102223552023-05-28 In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2 Villalobos-Sánchez, Erendira García-Ruiz, Daniel Camacho-Villegas, Tanya A. Canales-Aguirre, Alejandro A. Gutiérrez-Ortega, Abel Muñoz-Medina, José E. Elizondo-Quiroga, Darwin E. Viruses Article The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2. MDPI 2023-05-11 /pmc/articles/PMC10222355/ /pubmed/37243241 http://dx.doi.org/10.3390/v15051155 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Villalobos-Sánchez, Erendira
García-Ruiz, Daniel
Camacho-Villegas, Tanya A.
Canales-Aguirre, Alejandro A.
Gutiérrez-Ortega, Abel
Muñoz-Medina, José E.
Elizondo-Quiroga, Darwin E.
In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title_full In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title_fullStr In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title_full_unstemmed In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title_short In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
title_sort in vitro antiviral activity of nordihydroguaiaretic acid against sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222355/
https://www.ncbi.nlm.nih.gov/pubmed/37243241
http://dx.doi.org/10.3390/v15051155
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