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Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)

The study aimed to assess the trajectories of lifestyle characteristics and their association with 20-year cardiovascular disease (CVD) incidence. In 2002, 3042 Greek adults (aged: 45 (12) years) free of CVD were enrolled. In 2022, the 20-year follow-up was performed on 2169 participants; of those,...

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Autores principales: Damigou, Evangelia, Kouvari, Matina, Chrysohoou, Christina, Barkas, Fotios, Kravvariti, Evrydiki, Pitsavos, Christos, Skoumas, John, Michelis, Evangelinos, Liberopoulos, Evangelos, Tsioufis, Costas, Sfikakis, Petros P., Panagiotakos, Demosthenes B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222365/
https://www.ncbi.nlm.nih.gov/pubmed/37240787
http://dx.doi.org/10.3390/life13051142
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author Damigou, Evangelia
Kouvari, Matina
Chrysohoou, Christina
Barkas, Fotios
Kravvariti, Evrydiki
Pitsavos, Christos
Skoumas, John
Michelis, Evangelinos
Liberopoulos, Evangelos
Tsioufis, Costas
Sfikakis, Petros P.
Panagiotakos, Demosthenes B.
author_facet Damigou, Evangelia
Kouvari, Matina
Chrysohoou, Christina
Barkas, Fotios
Kravvariti, Evrydiki
Pitsavos, Christos
Skoumas, John
Michelis, Evangelinos
Liberopoulos, Evangelos
Tsioufis, Costas
Sfikakis, Petros P.
Panagiotakos, Demosthenes B.
author_sort Damigou, Evangelia
collection PubMed
description The study aimed to assess the trajectories of lifestyle characteristics and their association with 20-year cardiovascular disease (CVD) incidence. In 2002, 3042 Greek adults (aged: 45 (12) years) free of CVD were enrolled. In 2022, the 20-year follow-up was performed on 2169 participants; of those, 1988 had complete data for CVD. The 20-year CVD incidence was 3600 cases/10,000 individuals; the man-to-woman ratio was 1.25, with the peak difference in the 35–45 age group (i.e., 2.1); however, a reversal of the trend was observed in the age-groups 55–65 and 65–75, with a resumption of an almost equal incidence in those >75 years. In multi-adjusted analysis, age, sex, abnormal waist circumference, hypercholesterolemia, hypertension, and diabetes were positively associated with 20-year CVD risk, explaining 56% of the excess CVD risk, whereas an additional 30% was attributed to lifestyle trajectories; being physically active throughout life-course and being close to the Mediterranean diet were protective, while continuous smoking was detrimental against CVD risk. Mediterranean diet adherence protected against CVD development even if not sustained, while quitting smoking or engaging in physical activities during the 20-year observation did not offer any significant protection. A life-course personalized approach that is cost-effective and long-term sustained is needed to prevent CVD burden.
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spelling pubmed-102223652023-05-28 Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022) Damigou, Evangelia Kouvari, Matina Chrysohoou, Christina Barkas, Fotios Kravvariti, Evrydiki Pitsavos, Christos Skoumas, John Michelis, Evangelinos Liberopoulos, Evangelos Tsioufis, Costas Sfikakis, Petros P. Panagiotakos, Demosthenes B. Life (Basel) Article The study aimed to assess the trajectories of lifestyle characteristics and their association with 20-year cardiovascular disease (CVD) incidence. In 2002, 3042 Greek adults (aged: 45 (12) years) free of CVD were enrolled. In 2022, the 20-year follow-up was performed on 2169 participants; of those, 1988 had complete data for CVD. The 20-year CVD incidence was 3600 cases/10,000 individuals; the man-to-woman ratio was 1.25, with the peak difference in the 35–45 age group (i.e., 2.1); however, a reversal of the trend was observed in the age-groups 55–65 and 65–75, with a resumption of an almost equal incidence in those >75 years. In multi-adjusted analysis, age, sex, abnormal waist circumference, hypercholesterolemia, hypertension, and diabetes were positively associated with 20-year CVD risk, explaining 56% of the excess CVD risk, whereas an additional 30% was attributed to lifestyle trajectories; being physically active throughout life-course and being close to the Mediterranean diet were protective, while continuous smoking was detrimental against CVD risk. Mediterranean diet adherence protected against CVD development even if not sustained, while quitting smoking or engaging in physical activities during the 20-year observation did not offer any significant protection. A life-course personalized approach that is cost-effective and long-term sustained is needed to prevent CVD burden. MDPI 2023-05-08 /pmc/articles/PMC10222365/ /pubmed/37240787 http://dx.doi.org/10.3390/life13051142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Damigou, Evangelia
Kouvari, Matina
Chrysohoou, Christina
Barkas, Fotios
Kravvariti, Evrydiki
Pitsavos, Christos
Skoumas, John
Michelis, Evangelinos
Liberopoulos, Evangelos
Tsioufis, Costas
Sfikakis, Petros P.
Panagiotakos, Demosthenes B.
Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title_full Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title_fullStr Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title_full_unstemmed Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title_short Lifestyle Trajectories Are Associated with Incidence of Cardiovascular Disease: Highlights from the ATTICA Epidemiological Cohort Study (2002–2022)
title_sort lifestyle trajectories are associated with incidence of cardiovascular disease: highlights from the attica epidemiological cohort study (2002–2022)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222365/
https://www.ncbi.nlm.nih.gov/pubmed/37240787
http://dx.doi.org/10.3390/life13051142
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