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Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes

This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes, determine the effect of dietary protein intake on the serum metabolic profile, and examine its association with sarcopenia. Ninety-nine Japanese patients with type 2 diabetes...

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Autores principales: Nakajima, Hanako, Okada, Hiroshi, Kobayashi, Ayaka, Takahashi, Fuyuko, Okamura, Takuro, Hashimoto, Yoshitaka, Nakanishi, Naoko, Senmaru, Takafumi, Ushigome, Emi, Hamaguchi, Masahide, Fukui, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222500/
https://www.ncbi.nlm.nih.gov/pubmed/37242283
http://dx.doi.org/10.3390/nu15102400
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author Nakajima, Hanako
Okada, Hiroshi
Kobayashi, Ayaka
Takahashi, Fuyuko
Okamura, Takuro
Hashimoto, Yoshitaka
Nakanishi, Naoko
Senmaru, Takafumi
Ushigome, Emi
Hamaguchi, Masahide
Fukui, Michiaki
author_facet Nakajima, Hanako
Okada, Hiroshi
Kobayashi, Ayaka
Takahashi, Fuyuko
Okamura, Takuro
Hashimoto, Yoshitaka
Nakanishi, Naoko
Senmaru, Takafumi
Ushigome, Emi
Hamaguchi, Masahide
Fukui, Michiaki
author_sort Nakajima, Hanako
collection PubMed
description This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes, determine the effect of dietary protein intake on the serum metabolic profile, and examine its association with sarcopenia. Ninety-nine Japanese patients with type 2 diabetes were included, and sarcopenic risk was defined as low muscle mass or strength. Seventeen serum metabolites were quantified after gas chromatography–mass spectrometry analysis. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Twenty-seven patients were classified as being at risk of sarcopenia, the same as the general risk, which was associated with older age, a longer duration of the disease, and a lower body mass index. Low levels of leucine and glutamic acid were significantly associated with low muscle strength (p = 0.002 and p < 0.001, respectively), and leucine was also associated with muscle mass (p = 0.001). Lower levels of glutamic acid had higher odds of sarcopenic risk after being adjusted for age and HbA1c (adjusted OR 4.27, 95% CI 1.07–17.11, p = 0.041), but not for leucine. Leucine and glutamic acid can serve as useful biomarkers for sarcopenia, highlighting potential targets for its prevention.
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spelling pubmed-102225002023-05-28 Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes Nakajima, Hanako Okada, Hiroshi Kobayashi, Ayaka Takahashi, Fuyuko Okamura, Takuro Hashimoto, Yoshitaka Nakanishi, Naoko Senmaru, Takafumi Ushigome, Emi Hamaguchi, Masahide Fukui, Michiaki Nutrients Article This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes, determine the effect of dietary protein intake on the serum metabolic profile, and examine its association with sarcopenia. Ninety-nine Japanese patients with type 2 diabetes were included, and sarcopenic risk was defined as low muscle mass or strength. Seventeen serum metabolites were quantified after gas chromatography–mass spectrometry analysis. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Twenty-seven patients were classified as being at risk of sarcopenia, the same as the general risk, which was associated with older age, a longer duration of the disease, and a lower body mass index. Low levels of leucine and glutamic acid were significantly associated with low muscle strength (p = 0.002 and p < 0.001, respectively), and leucine was also associated with muscle mass (p = 0.001). Lower levels of glutamic acid had higher odds of sarcopenic risk after being adjusted for age and HbA1c (adjusted OR 4.27, 95% CI 1.07–17.11, p = 0.041), but not for leucine. Leucine and glutamic acid can serve as useful biomarkers for sarcopenia, highlighting potential targets for its prevention. MDPI 2023-05-21 /pmc/articles/PMC10222500/ /pubmed/37242283 http://dx.doi.org/10.3390/nu15102400 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakajima, Hanako
Okada, Hiroshi
Kobayashi, Ayaka
Takahashi, Fuyuko
Okamura, Takuro
Hashimoto, Yoshitaka
Nakanishi, Naoko
Senmaru, Takafumi
Ushigome, Emi
Hamaguchi, Masahide
Fukui, Michiaki
Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title_full Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title_fullStr Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title_full_unstemmed Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title_short Leucine and Glutamic Acid as a Biomarker of Sarcopenic Risk in Japanese People with Type 2 Diabetes
title_sort leucine and glutamic acid as a biomarker of sarcopenic risk in japanese people with type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222500/
https://www.ncbi.nlm.nih.gov/pubmed/37242283
http://dx.doi.org/10.3390/nu15102400
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