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Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis

Introduction: There is a well-documented association between coronary artery disease (CHD) and periodontal disease (PD) mediated by common inflammatory pathways. This association, however, has not been investigated extensively in the special context of in-stent restenosis. This study aimed to invest...

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Autores principales: Nagy, Ferenc Tamás, Gheorghita, Dorottya, Dharmarajan, Lalli, Braunitzer, Gábor, Achim, Alexandru, Ruzsa, Zoltán, Antal, Márk Ádám
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222515/
https://www.ncbi.nlm.nih.gov/pubmed/37240930
http://dx.doi.org/10.3390/jpm13050760
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author Nagy, Ferenc Tamás
Gheorghita, Dorottya
Dharmarajan, Lalli
Braunitzer, Gábor
Achim, Alexandru
Ruzsa, Zoltán
Antal, Márk Ádám
author_facet Nagy, Ferenc Tamás
Gheorghita, Dorottya
Dharmarajan, Lalli
Braunitzer, Gábor
Achim, Alexandru
Ruzsa, Zoltán
Antal, Márk Ádám
author_sort Nagy, Ferenc Tamás
collection PubMed
description Introduction: There is a well-documented association between coronary artery disease (CHD) and periodontal disease (PD) mediated by common inflammatory pathways. This association, however, has not been investigated extensively in the special context of in-stent restenosis. This study aimed to investigate the periodontal status of patients undergoing percutaneous coronary intervention (PCI) for restenotic lesions. Methods and Results: We enrolled 90 patients undergoing percutaneous coronary intervention and 90 age- and gender-matched healthy controls in the present study. All subjects received a full-mouth examination by a periodontist. Plaque index, periodontal status, and tooth loss were determined. The periodontal state was significantly worse (p < 0.0001) in the PCI group, and each periodontal stage increased the odds of belonging to the PCI group. This effect of PD was independent of diabetes mellitus, another strong risk factor for CAD. The PCI group was further divided into two subgroups: PCI for restenotic lesions (n = 39) and PCI for de novo lesions (n = 51). Baseline clinical and procedural characteristics were comparable between the two PCI subgroups. A significant (p < 0.001) association was found between the PCI subgroup and the severity of periodontal disease, with the incidence of severe PD reaching 64.1%. Conclusions: Patients undergoing PCI for in-stent restenosis exhibit more severe forms of periodontal disease not only as compared to healthy controls but also as compared to patients stented for de novo lesions. The potential causality between PD and restenosis must be studied in larger prospective studies.
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spelling pubmed-102225152023-05-28 Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis Nagy, Ferenc Tamás Gheorghita, Dorottya Dharmarajan, Lalli Braunitzer, Gábor Achim, Alexandru Ruzsa, Zoltán Antal, Márk Ádám J Pers Med Article Introduction: There is a well-documented association between coronary artery disease (CHD) and periodontal disease (PD) mediated by common inflammatory pathways. This association, however, has not been investigated extensively in the special context of in-stent restenosis. This study aimed to investigate the periodontal status of patients undergoing percutaneous coronary intervention (PCI) for restenotic lesions. Methods and Results: We enrolled 90 patients undergoing percutaneous coronary intervention and 90 age- and gender-matched healthy controls in the present study. All subjects received a full-mouth examination by a periodontist. Plaque index, periodontal status, and tooth loss were determined. The periodontal state was significantly worse (p < 0.0001) in the PCI group, and each periodontal stage increased the odds of belonging to the PCI group. This effect of PD was independent of diabetes mellitus, another strong risk factor for CAD. The PCI group was further divided into two subgroups: PCI for restenotic lesions (n = 39) and PCI for de novo lesions (n = 51). Baseline clinical and procedural characteristics were comparable between the two PCI subgroups. A significant (p < 0.001) association was found between the PCI subgroup and the severity of periodontal disease, with the incidence of severe PD reaching 64.1%. Conclusions: Patients undergoing PCI for in-stent restenosis exhibit more severe forms of periodontal disease not only as compared to healthy controls but also as compared to patients stented for de novo lesions. The potential causality between PD and restenosis must be studied in larger prospective studies. MDPI 2023-04-28 /pmc/articles/PMC10222515/ /pubmed/37240930 http://dx.doi.org/10.3390/jpm13050760 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nagy, Ferenc Tamás
Gheorghita, Dorottya
Dharmarajan, Lalli
Braunitzer, Gábor
Achim, Alexandru
Ruzsa, Zoltán
Antal, Márk Ádám
Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title_full Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title_fullStr Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title_full_unstemmed Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title_short Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis
title_sort oral health of patients undergoing percutaneous coronary intervention—a possible link between periodontal disease and in-stent restenosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222515/
https://www.ncbi.nlm.nih.gov/pubmed/37240930
http://dx.doi.org/10.3390/jpm13050760
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