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An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered Salmonella for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model

Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. This study explored an engineered Salmonella as a vaccine carrier to deliver a eukaryotic self-mRNA replicating vector, pJHL204. This vector expresses multiple SFTS virus ant...

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Detalles Bibliográficos
Autores principales:	Park, Ji-Young, Hewawaduge, Chamith, Sivasankar, Chandran, Lloren, Khristine Kaith S., Oh, Byungkwan, So, Mi Young, Lee, John Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222543/ https://www.ncbi.nlm.nih.gov/pubmed/37242581 http://dx.doi.org/10.3390/pharmaceutics15051339

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