Cargando…

Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant

HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously developed an ultra-long-acting injectable, biodegrad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Young, Isabella C., Thorson, Allison L., Shrivastava, Roopali, Sykes, Craig, Schauer, Amanda P., Cottrell, Mackenzie L., Kashuba, Angela D. M., Benhabbour, Soumya Rahima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222572/ https://www.ncbi.nlm.nih.gov/pubmed/37242729 http://dx.doi.org/10.3390/pharmaceutics15051487

Ejemplares similares

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection
por: Young, Isabella C., et al.
Publicado: (2023)

Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics
por: Joiner, Jordan B., et al.
Publicado: (2022)

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
por: Benhabbour, S. Rahima, et al.
Publicado: (2019)

Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics
por: Joiner, Jordan B., et al.
Publicado: (2022)

Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration
por: King, Jasmine L., et al.
Publicado: (2023)

A new engineering process of biodegradable polymeric solid implants for ultra-long-acting drug delivery
por: Maturavongsadit, Panita, et al.
Publicado: (2020)

2153: Innovative 3D printed intravaginal rings for contraception and HIV prevention
por: Benhabbour, Rahima, et al.
Publicado: (2018)

Multipurpose Prevention Technologies: Oral, Parenteral, and Vaginal Dosage Forms for Prevention of HIV/STIs and Unplanned Pregnancy
por: Young, Isabella C., et al.
Publicado: (2021)

Glioblastoma Multiforme—A Look at the Past and a Glance at the Future
por: King, Jasmine L., et al.
Publicado: (2021)

Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment
por: Parasrampuria, Ridhi, et al.
Publicado: (2017)

Pharmacokinetics of Cabotegravir in Subjects with Moderate Hepatic Impairment
por: Shaik, Jafar Sadik, et al.
Publicado: (2017)

Ultra-long-acting removable drug delivery system for HIV treatment and prevention
por: Kovarova, Martina, et al.
Publicado: (2018)

Non-Hormonal Contraception
por: Howard, Sarah Anne, et al.
Publicado: (2023)

Cabotegravir
Publicado: (2022)

Effect of Rifampin on the Single-Dose Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
por: Ford, S. L., et al.
Publicado: (2017)

Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis
por: Prasher, Alka, et al.
Publicado: (2021)

Effect of a High‐Fat Meal on the Pharmacokinetics of the HIV Integrase Inhibitor Cabotegravir
por: Patel, Parul, et al.
Publicado: (2018)

Pharmacokinetics and Drug–Drug Interactions of Long-Acting Intramuscular Cabotegravir and Rilpivirine
por: Hodge, Daryl, et al.
Publicado: (2021)

Multicompartmental pharmacokinetic evaluation of long‐acting cabotegravir in healthy adults for HIV preexposure prophylaxis
por: Shaik, Jafar Sadik, et al.
Publicado: (2021)

Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques
por: Kleinman, Adam J., et al.
Publicado: (2020)

Safety, Tolerability, Pharmacokinetics, and Acceptability of Oral and Long-Acting Cabotegravir in HIV-Negative Chinese Men
por: Han, Kelong, et al.
Publicado: (2022)

A Pharmacokinetic Dose-Optimization Study of Cabotegravir and Bictegravir in a Mouse Pregnancy Model
por: Mohan, Haneesha, et al.
Publicado: (2022)

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir
por: Gautam, Nagsen, et al.
Publicado: (2021)

3466 Innovative 3D Printed Intravaginal Rings: Developing AnelleO PRO, the First Intravaginal Ring for Infertility
por: Janusziewicz, Rima, et al.
Publicado: (2019)

Formulation and pharmacology of long-acting cabotegravir
por: Trezza, Christine, et al.
Publicado: (2015)

The Current Landscape of Glioblastoma Biomarkers in Body Fluids
por: Zanganeh, Saba, et al.
Publicado: (2023)

EFdA efficiently suppresses HIV replication in the male genital tract and prevents penile HIV acquisition
por: Kovarova, Martina, et al.
Publicado: (2023)

A Phase 1 Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Patients With Hepatic Impairment and Healthy Matched Controls
por: Shaik, Jafar Sadik B., et al.
Publicado: (2019)

Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects
por: Lou, Yu, et al.
Publicado: (2016)

Evaluation of the effect of UGT1A1 polymorphisms on the pharmacokinetics of oral and long-acting injectable cabotegravir
por: Patel, Parul, et al.
Publicado: (2020)

Cabotegravir Exposure of Zebrafish (Danio rerio) Embryos Impacts on Neurodevelopment and Behavior
por: Zizioli, Daniela, et al.
Publicado: (2023)

Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol‐containing oral contraceptive in healthy adult women
por: Trezza, Christine, et al.
Publicado: (2017)

Injectable pH Thermo-Responsive Hydrogel Scaffold for Tumoricidal Neural Stem Cell Therapy for Glioblastoma Multiforme
por: King, Jasmine L., et al.
Publicado: (2022)

Pharmacokinetics and antiviral activity of cabotegravir and rilpivirine in cerebrospinal fluid following long-acting injectable administration in HIV-infected adults
por: Letendre, Scott L, et al.
Publicado: (2020)

885. Pregnancy Outcomes and Pharmacokinetics in Pregnant Women Living with HIV Exposed to Long-Acting Cabotegravir and Rilpivirine in Clinical Trials
por: Patel, Parul, et al.
Publicado: (2021)

A Phase I Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Adults With Severe Renal Impairment and Healthy Matched Control Participants
por: Parasrampuria, Ridhi, et al.
Publicado: (2019)

Long-Acting Injectable Cabotegravir for HIV Prevention: What Do We Know and Need to Know about the Risks and Consequences of Cabotegravir Resistance?
por: Parikh, Urvi M., et al.
Publicado: (2022)

Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects
por: Han, Kelong, et al.
Publicado: (2022)

A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug
por: Kulkarni, Tanmay A., et al.
Publicado: (2020)

2′-(2-bromohexadecanoyl)-paclitaxel conjugate nanoparticles for the treatment of non-small cell lung cancer in an orthotopic xenograft mouse model
por: Peng, Lei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ac5hmlskih2sebld8pojo9eo7u