Cargando…

Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study

Background: Pakistan has subpar childhood immunization rates and immunization activities have faced several challenges over the past years. We evaluated the social-behavioral and cultural barriers and risk factors for refusal of polio, Routine Immunization (RI), or both in high-risk areas of poliovi...

Descripción completa

Detalles Bibliográficos
Autores principales: Soofi, Sajid Bashir, Vadsaria, Khadija, Mannan, Sara, Habib, Muhammad Atif, Tabassum, Farhana, Hussain, Imtiaz, Muhammad, Sajid, Feroz, Khalid, Ahmed, Imran, Islam, Muhammad, Bhutta, Zulfiqar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222589/
https://www.ncbi.nlm.nih.gov/pubmed/37243051
http://dx.doi.org/10.3390/vaccines11050947
_version_ 1785049735106658304
author Soofi, Sajid Bashir
Vadsaria, Khadija
Mannan, Sara
Habib, Muhammad Atif
Tabassum, Farhana
Hussain, Imtiaz
Muhammad, Sajid
Feroz, Khalid
Ahmed, Imran
Islam, Muhammad
Bhutta, Zulfiqar A.
author_facet Soofi, Sajid Bashir
Vadsaria, Khadija
Mannan, Sara
Habib, Muhammad Atif
Tabassum, Farhana
Hussain, Imtiaz
Muhammad, Sajid
Feroz, Khalid
Ahmed, Imran
Islam, Muhammad
Bhutta, Zulfiqar A.
author_sort Soofi, Sajid Bashir
collection PubMed
description Background: Pakistan has subpar childhood immunization rates and immunization activities have faced several challenges over the past years. We evaluated the social-behavioral and cultural barriers and risk factors for refusal of polio, Routine Immunization (RI), or both in high-risk areas of poliovirus circulation. Methods: A matched case-control study was conducted from April to July 2017 in eight super high-risk Union Councils of five towns in Karachi, Pakistan. A total of 3 groups, each with 250 cases, including refusals for the Oral Polio Vaccine (OPV) in campaigns (national immunization days and supplementary immunization activities), RI, and both, were matched with 500 controls and identified using surveillance records. Sociodemographic characteristics, household information, and immunization history were assessed. Study outcomes included social-behavioral and cultural barriers and reasons for vaccine refusal. Data were analyzed in STATA using conditional logistic regression. Results: RI refusal was associated with illiteracy and fear of the vaccine’s adverse effects, while OPV refusals were linked to the mother’s decision authority and the assumption that the OPV caused infertility. Conversely, higher socioeconomic status (SES) and knowledge of and willingness to vaccinate with Inactivated Polio Vaccine (IPV) were inversely associated with RI; and lower SES, walking to the vaccination point, knowledge of IPV, and an understanding of contracting polio were inversely associated with OPV refusals, with the latter two also inversely associated with complete vaccine refusal. Conclusion: Education, knowledge and understanding of vaccines, and socioeconomic determinants influenced OPV and RI refusals among children. Effective interventions are needed to address knowledge gaps and misconceptions among parents.
format Online
Article
Text
id pubmed-10222589
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102225892023-05-28 Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study Soofi, Sajid Bashir Vadsaria, Khadija Mannan, Sara Habib, Muhammad Atif Tabassum, Farhana Hussain, Imtiaz Muhammad, Sajid Feroz, Khalid Ahmed, Imran Islam, Muhammad Bhutta, Zulfiqar A. Vaccines (Basel) Article Background: Pakistan has subpar childhood immunization rates and immunization activities have faced several challenges over the past years. We evaluated the social-behavioral and cultural barriers and risk factors for refusal of polio, Routine Immunization (RI), or both in high-risk areas of poliovirus circulation. Methods: A matched case-control study was conducted from April to July 2017 in eight super high-risk Union Councils of five towns in Karachi, Pakistan. A total of 3 groups, each with 250 cases, including refusals for the Oral Polio Vaccine (OPV) in campaigns (national immunization days and supplementary immunization activities), RI, and both, were matched with 500 controls and identified using surveillance records. Sociodemographic characteristics, household information, and immunization history were assessed. Study outcomes included social-behavioral and cultural barriers and reasons for vaccine refusal. Data were analyzed in STATA using conditional logistic regression. Results: RI refusal was associated with illiteracy and fear of the vaccine’s adverse effects, while OPV refusals were linked to the mother’s decision authority and the assumption that the OPV caused infertility. Conversely, higher socioeconomic status (SES) and knowledge of and willingness to vaccinate with Inactivated Polio Vaccine (IPV) were inversely associated with RI; and lower SES, walking to the vaccination point, knowledge of IPV, and an understanding of contracting polio were inversely associated with OPV refusals, with the latter two also inversely associated with complete vaccine refusal. Conclusion: Education, knowledge and understanding of vaccines, and socioeconomic determinants influenced OPV and RI refusals among children. Effective interventions are needed to address knowledge gaps and misconceptions among parents. MDPI 2023-05-05 /pmc/articles/PMC10222589/ /pubmed/37243051 http://dx.doi.org/10.3390/vaccines11050947 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soofi, Sajid Bashir
Vadsaria, Khadija
Mannan, Sara
Habib, Muhammad Atif
Tabassum, Farhana
Hussain, Imtiaz
Muhammad, Sajid
Feroz, Khalid
Ahmed, Imran
Islam, Muhammad
Bhutta, Zulfiqar A.
Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title_full Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title_fullStr Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title_full_unstemmed Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title_short Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study
title_sort factors associated with vaccine refusal (polio and routine immunization) in high-risk areas of pakistan: a matched case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222589/
https://www.ncbi.nlm.nih.gov/pubmed/37243051
http://dx.doi.org/10.3390/vaccines11050947
work_keys_str_mv AT soofisajidbashir factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT vadsariakhadija factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT mannansara factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT habibmuhammadatif factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT tabassumfarhana factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT hussainimtiaz factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT muhammadsajid factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT ferozkhalid factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT ahmedimran factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT islammuhammad factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy
AT bhuttazulfiqara factorsassociatedwithvaccinerefusalpolioandroutineimmunizationinhighriskareasofpakistanamatchedcasecontrolstudy