Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis

Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy. However, the features of the tool compound used in those stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Wubben, Thomas J., Chaudhury, Sraboni, Watch, Brennan T., Stuckey, Jeanne A., Weh, Eric, Fernando, Roshini, Goswami, Moloy, Pawar, Mercy, Rech, Jason C., Besirli, Cagri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222839/
https://www.ncbi.nlm.nih.gov/pubmed/37242488
http://dx.doi.org/10.3390/ph16050705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222839/
https://www.ncbi.nlm.nih.gov/pubmed/37242488
http://dx.doi.org/10.3390/ph16050705

Ejemplares similares