Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration. In this work, we characterize a novel P-III class snake venom metalloproteinase, called pictolysin-III (Pic-III). It is a 62 kDa...

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Detalles Bibliográficos
Autores principales: Vivas-Ruiz, Dan E., Rosas, Paola, Proleón, Alex, Torrejón, Daniel, Lazo, Fanny, Tenorio-Ricca, Ana Belén, Guajardo, Francisco, Almarza, Cristopher, Andrades, Víctor, Astorga, Jessica, Oropesa, Daniel, Toledo, Jorge, Vera, María Jesús, Martínez, Jorge, Araya-Maturana, Ramiro, Dubois-Camacho, Karen, Hermoso, Marcela A., Alvarenga, Valéria G., Sanchez, Eladio Flores, Yarlequé, Armando, Oliveira, Luciana Souza, Urra, Félix A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222873/
https://www.ncbi.nlm.nih.gov/pubmed/37242775
http://dx.doi.org/10.3390/pharmaceutics15051533

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