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Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria
Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the bloodstream and PQ acting against liver stages...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223033/ https://www.ncbi.nlm.nih.gov/pubmed/37235326 http://dx.doi.org/10.3390/tropicalmed8050278 |
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author | Markus, Miles B. |
author_facet | Markus, Miles B. |
author_sort | Markus, Miles B. |
collection | PubMed |
description | Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the bloodstream and PQ acting against liver stages. However, PQ’s contribution, if any, to inactivating non-circulating, extra-hepatic asexual forms, which make up the bulk of the parasite biomass in chronic P. vivax infections, remains unclear. In this opinion article, I suggest that, considering its newly described mode of action, PQ might be doing something of which we are currently unaware. |
format | Online Article Text |
id | pubmed-10223033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102230332023-05-28 Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria Markus, Miles B. Trop Med Infect Dis Opinion Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the bloodstream and PQ acting against liver stages. However, PQ’s contribution, if any, to inactivating non-circulating, extra-hepatic asexual forms, which make up the bulk of the parasite biomass in chronic P. vivax infections, remains unclear. In this opinion article, I suggest that, considering its newly described mode of action, PQ might be doing something of which we are currently unaware. MDPI 2023-05-15 /pmc/articles/PMC10223033/ /pubmed/37235326 http://dx.doi.org/10.3390/tropicalmed8050278 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Markus, Miles B. Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title | Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title_full | Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title_fullStr | Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title_full_unstemmed | Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title_short | Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria |
title_sort | putative contribution of 8-aminoquinolines to preventing recrudescence of malaria |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223033/ https://www.ncbi.nlm.nih.gov/pubmed/37235326 http://dx.doi.org/10.3390/tropicalmed8050278 |
work_keys_str_mv | AT markusmilesb putativecontributionof8aminoquinolinestopreventingrecrudescenceofmalaria |