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Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review

(1) Background: Cryptogenic Klebsiella pneumoniae liver abscesses are an invasive infection with or without extra hepatic involvement in the absence of hepatobiliary disease or abdominal malignancy. Most of the evidence has emanated from reports from Asia, and previous studies in the Americas have l...

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Autores principales: Cardenas-Alvarez, Jorge, Balayla, Galit, Triana, Abel, Diaz Lankenau, Rodrigo, Franco-Paredes, Carlos, Henao-Martínez, Andrés F., Motoa, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223038/
https://www.ncbi.nlm.nih.gov/pubmed/37242331
http://dx.doi.org/10.3390/pathogens12050661
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author Cardenas-Alvarez, Jorge
Balayla, Galit
Triana, Abel
Diaz Lankenau, Rodrigo
Franco-Paredes, Carlos
Henao-Martínez, Andrés F.
Motoa, Gabriel
author_facet Cardenas-Alvarez, Jorge
Balayla, Galit
Triana, Abel
Diaz Lankenau, Rodrigo
Franco-Paredes, Carlos
Henao-Martínez, Andrés F.
Motoa, Gabriel
author_sort Cardenas-Alvarez, Jorge
collection PubMed
description (1) Background: Cryptogenic Klebsiella pneumoniae liver abscesses are an invasive infection with or without extra hepatic involvement in the absence of hepatobiliary disease or abdominal malignancy. Most of the evidence has emanated from reports from Asia, and previous studies in the Americas have limited clinical characterization. (2) Methods: To understand this syndrome’s characteristics on our continent, we conducted a scoping review to identify adult cases of idiopathic, community-acquired monomicrobial K. pneumoniae liver abscess in the Americas. (3) Results: We identified 144 cases spanning 1978–2022. Most cases were reported in males that had traveled or migrated from Southeast or East Asia with diabetes mellitus. Extrahepatic involvement and bacteremia were common, including seeding to the lungs, ocular structures, and central nervous system. Although limited by sample size, the most commonly reported genes were magA or rmpA. Concomitant percutaneous drainage and third generation cephalosporins (alone or in combination with other antibiotics) were frequently used, yet pooled fatality occurred in 9% of the reported cases. (4) Conclusions: The features of cryptogenic K. pneumoniae liver abscess in the Americas mirror those described in Asia, confirming its global dissemination. This condition is increasingly being reported in our continent and carries significant clinical impact due to its systemic invasiveness.
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spelling pubmed-102230382023-05-28 Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review Cardenas-Alvarez, Jorge Balayla, Galit Triana, Abel Diaz Lankenau, Rodrigo Franco-Paredes, Carlos Henao-Martínez, Andrés F. Motoa, Gabriel Pathogens Systematic Review (1) Background: Cryptogenic Klebsiella pneumoniae liver abscesses are an invasive infection with or without extra hepatic involvement in the absence of hepatobiliary disease or abdominal malignancy. Most of the evidence has emanated from reports from Asia, and previous studies in the Americas have limited clinical characterization. (2) Methods: To understand this syndrome’s characteristics on our continent, we conducted a scoping review to identify adult cases of idiopathic, community-acquired monomicrobial K. pneumoniae liver abscess in the Americas. (3) Results: We identified 144 cases spanning 1978–2022. Most cases were reported in males that had traveled or migrated from Southeast or East Asia with diabetes mellitus. Extrahepatic involvement and bacteremia were common, including seeding to the lungs, ocular structures, and central nervous system. Although limited by sample size, the most commonly reported genes were magA or rmpA. Concomitant percutaneous drainage and third generation cephalosporins (alone or in combination with other antibiotics) were frequently used, yet pooled fatality occurred in 9% of the reported cases. (4) Conclusions: The features of cryptogenic K. pneumoniae liver abscess in the Americas mirror those described in Asia, confirming its global dissemination. This condition is increasingly being reported in our continent and carries significant clinical impact due to its systemic invasiveness. MDPI 2023-04-29 /pmc/articles/PMC10223038/ /pubmed/37242331 http://dx.doi.org/10.3390/pathogens12050661 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Cardenas-Alvarez, Jorge
Balayla, Galit
Triana, Abel
Diaz Lankenau, Rodrigo
Franco-Paredes, Carlos
Henao-Martínez, Andrés F.
Motoa, Gabriel
Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title_full Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title_fullStr Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title_full_unstemmed Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title_short Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review
title_sort clinical spectrum and outcomes of cryptogenic klebsiella pneumoniae liver abscess in the americas: a scoping review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223038/
https://www.ncbi.nlm.nih.gov/pubmed/37242331
http://dx.doi.org/10.3390/pathogens12050661
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