Cargando…

Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults

Evidence suggests that diet can play a role in modulating systemic inflammation. This study aims to examine the relationship between fatty acids (FAs) (self-reported dietary intake and red blood cell (RBC) membrane fatty acid concentrations), three diet quality scores, and the plasma concentrations...

Descripción completa

Detalles Bibliográficos
Autores principales: Clarke, Erin D., Stanford, Jordan, Ferguson, Jessica J. A., Wood, Lisa G., Collins, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223124/
https://www.ncbi.nlm.nih.gov/pubmed/37242288
http://dx.doi.org/10.3390/nu15102405
_version_ 1785049866140909568
author Clarke, Erin D.
Stanford, Jordan
Ferguson, Jessica J. A.
Wood, Lisa G.
Collins, Clare E.
author_facet Clarke, Erin D.
Stanford, Jordan
Ferguson, Jessica J. A.
Wood, Lisa G.
Collins, Clare E.
author_sort Clarke, Erin D.
collection PubMed
description Evidence suggests that diet can play a role in modulating systemic inflammation. This study aims to examine the relationship between fatty acids (FAs) (self-reported dietary intake and red blood cell (RBC) membrane fatty acid concentrations), three diet quality scores, and the plasma concentrations of inflammatory markers (interleukin-6, IL-6; tumour necrosis factor alpha, TNF-α; and C-reactive protein, CRP) in a group of Australian adults (n = 92). Data were collected on their demographic characteristics, health status, supplement intake, dietary intake, RBC-FAs and plasma inflammatory markers over a nine-month period. Mixed-effects models were used to determine the relationship between RBC-FAs, dietary intake of FAs, diet quality scores and inflammatory markers to determine which variable most strongly predicted systemic inflammation. A significant association was identified between dietary saturated fat intake and TNF-α (β = 0.01, p < 0.05). An association was also identified between RBC membrane saturated fatty acids (SFA) and CRP (β = 0.55, p < 0.05). Inverse associations were identified between RBC membrane monounsaturated fatty acids (MUFAs) (β = −0.88, p < 0.01), dietary polyunsaturated fatty acids (PUFAs) (β = −0.21, p < 0.05) and CRP, and the Australian Eating Survey Modified Mediterranean Diet (AES-MED) score and IL-6 (β = −0.21, p < 0.05). In summary, using both objective and subjective measures of fat intake and diet quality, our study has confirmed a positive association between saturated fat and inflammation, while inverse associations were observed between MUFAs, PUFAs, the Mediterranean diet, and inflammation. Our results provide further evidence that manipulating diet quality, in particular fatty acid intake, may be useful for reducing chronic systemic inflammation.
format Online
Article
Text
id pubmed-10223124
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102231242023-05-28 Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults Clarke, Erin D. Stanford, Jordan Ferguson, Jessica J. A. Wood, Lisa G. Collins, Clare E. Nutrients Article Evidence suggests that diet can play a role in modulating systemic inflammation. This study aims to examine the relationship between fatty acids (FAs) (self-reported dietary intake and red blood cell (RBC) membrane fatty acid concentrations), three diet quality scores, and the plasma concentrations of inflammatory markers (interleukin-6, IL-6; tumour necrosis factor alpha, TNF-α; and C-reactive protein, CRP) in a group of Australian adults (n = 92). Data were collected on their demographic characteristics, health status, supplement intake, dietary intake, RBC-FAs and plasma inflammatory markers over a nine-month period. Mixed-effects models were used to determine the relationship between RBC-FAs, dietary intake of FAs, diet quality scores and inflammatory markers to determine which variable most strongly predicted systemic inflammation. A significant association was identified between dietary saturated fat intake and TNF-α (β = 0.01, p < 0.05). An association was also identified between RBC membrane saturated fatty acids (SFA) and CRP (β = 0.55, p < 0.05). Inverse associations were identified between RBC membrane monounsaturated fatty acids (MUFAs) (β = −0.88, p < 0.01), dietary polyunsaturated fatty acids (PUFAs) (β = −0.21, p < 0.05) and CRP, and the Australian Eating Survey Modified Mediterranean Diet (AES-MED) score and IL-6 (β = −0.21, p < 0.05). In summary, using both objective and subjective measures of fat intake and diet quality, our study has confirmed a positive association between saturated fat and inflammation, while inverse associations were observed between MUFAs, PUFAs, the Mediterranean diet, and inflammation. Our results provide further evidence that manipulating diet quality, in particular fatty acid intake, may be useful for reducing chronic systemic inflammation. MDPI 2023-05-21 /pmc/articles/PMC10223124/ /pubmed/37242288 http://dx.doi.org/10.3390/nu15102405 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clarke, Erin D.
Stanford, Jordan
Ferguson, Jessica J. A.
Wood, Lisa G.
Collins, Clare E.
Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title_full Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title_fullStr Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title_full_unstemmed Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title_short Red Blood Cell Membrane Fatty Acid Composition, Dietary Fatty Acid Intake and Diet Quality as Predictors of Inflammation in a Group of Australian Adults
title_sort red blood cell membrane fatty acid composition, dietary fatty acid intake and diet quality as predictors of inflammation in a group of australian adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223124/
https://www.ncbi.nlm.nih.gov/pubmed/37242288
http://dx.doi.org/10.3390/nu15102405
work_keys_str_mv AT clarkeerind redbloodcellmembranefattyacidcompositiondietaryfattyacidintakeanddietqualityaspredictorsofinflammationinagroupofaustralianadults
AT stanfordjordan redbloodcellmembranefattyacidcompositiondietaryfattyacidintakeanddietqualityaspredictorsofinflammationinagroupofaustralianadults
AT fergusonjessicaja redbloodcellmembranefattyacidcompositiondietaryfattyacidintakeanddietqualityaspredictorsofinflammationinagroupofaustralianadults
AT woodlisag redbloodcellmembranefattyacidcompositiondietaryfattyacidintakeanddietqualityaspredictorsofinflammationinagroupofaustralianadults
AT collinsclaree redbloodcellmembranefattyacidcompositiondietaryfattyacidintakeanddietqualityaspredictorsofinflammationinagroupofaustralianadults