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Molecular Basis of TcdR-Dependent Promoter Activity for Toxin Production by Clostridioides difficile Studied by a Heterologous Reporter System

The alternative σ factor TcdR controls the synthesis of two major enterotoxins: TcdA and TcdB in Clostridioides difficile. Four potential TcdR-dependent promoters in the pathogenicity locus of C. difficile showed different activities. In this study, we constructed a heterologous system in Bacillus s...

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Detalles Bibliográficos
Autores principales:	Zhang, Xinyue, Li, Jie, Chen, Chao, Liu, Ya-Jun, Cui, Qiu, Hong, Wei, Chen, Zhenghong, Feng, Yingang, Cui, Guzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223161/ https://www.ncbi.nlm.nih.gov/pubmed/37235341 http://dx.doi.org/10.3390/toxins15050306

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