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Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19

Background: Mitochondrial dysfunction and redox cellular imbalance indicate crucial function in COVID-19 pathogenesis. Since 11 March 2020, a global pandemic, health crisis and economic disruption has been caused by SARS-CoV-2 virus. Vaccination is considered one of the most effective strategies for...

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Autores principales: Gvozdjáková, Anna, Kucharská, Jarmila, Rausová, Zuzana, Lopéz-Lluch, Guillermo, Navas, Plácido, Palacka, Patrik, Bartolčičová, Barbora, Sumbalová, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223181/
https://www.ncbi.nlm.nih.gov/pubmed/37243171
http://dx.doi.org/10.3390/v15051085
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author Gvozdjáková, Anna
Kucharská, Jarmila
Rausová, Zuzana
Lopéz-Lluch, Guillermo
Navas, Plácido
Palacka, Patrik
Bartolčičová, Barbora
Sumbalová, Zuzana
author_facet Gvozdjáková, Anna
Kucharská, Jarmila
Rausová, Zuzana
Lopéz-Lluch, Guillermo
Navas, Plácido
Palacka, Patrik
Bartolčičová, Barbora
Sumbalová, Zuzana
author_sort Gvozdjáková, Anna
collection PubMed
description Background: Mitochondrial dysfunction and redox cellular imbalance indicate crucial function in COVID-19 pathogenesis. Since 11 March 2020, a global pandemic, health crisis and economic disruption has been caused by SARS-CoV-2 virus. Vaccination is considered one of the most effective strategies for preventing viral infection. We tested the hypothesis that preventive vaccination affects the reduced bioenergetics of platelet mitochondria and the biosynthesis of endogenous coenzyme Q(10) (CoQ(10)) in patients with post-acute COVID-19. Material and Methods: 10 vaccinated patients with post-acute COVID-19 (V + PAC19) and 10 unvaccinated patients with post-acute COVID-19 (PAC19) were included in the study. The control group (C) consisted of 16 healthy volunteers. Platelet mitochondrial bioenergy function was determined with HRR method. CoQ(10), γ-tocopherol, α-tocopherol and β-carotene were determined by HPLC, TBARS (thiobarbituric acid reactive substances) were determined spectrophotometrically. Results: Vaccination protected platelet mitochondrial bioenergy function but not endogenous CoQ(10) levels, in patients with post-acute COVID-19. Conclusions: Vaccination against SARS-CoV-2 virus infection prevented the reduction of platelet mitochondrial respiration and energy production. The mechanism of suppression of CoQ(10) levels by SARS-CoV-2 virus is not fully known. Methods for the determination of CoQ(10) and HRR can be used for monitoring of mitochondrial bioenergetics and targeted therapy of patients with post-acute COVID-19.
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spelling pubmed-102231812023-05-28 Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19 Gvozdjáková, Anna Kucharská, Jarmila Rausová, Zuzana Lopéz-Lluch, Guillermo Navas, Plácido Palacka, Patrik Bartolčičová, Barbora Sumbalová, Zuzana Viruses Article Background: Mitochondrial dysfunction and redox cellular imbalance indicate crucial function in COVID-19 pathogenesis. Since 11 March 2020, a global pandemic, health crisis and economic disruption has been caused by SARS-CoV-2 virus. Vaccination is considered one of the most effective strategies for preventing viral infection. We tested the hypothesis that preventive vaccination affects the reduced bioenergetics of platelet mitochondria and the biosynthesis of endogenous coenzyme Q(10) (CoQ(10)) in patients with post-acute COVID-19. Material and Methods: 10 vaccinated patients with post-acute COVID-19 (V + PAC19) and 10 unvaccinated patients with post-acute COVID-19 (PAC19) were included in the study. The control group (C) consisted of 16 healthy volunteers. Platelet mitochondrial bioenergy function was determined with HRR method. CoQ(10), γ-tocopherol, α-tocopherol and β-carotene were determined by HPLC, TBARS (thiobarbituric acid reactive substances) were determined spectrophotometrically. Results: Vaccination protected platelet mitochondrial bioenergy function but not endogenous CoQ(10) levels, in patients with post-acute COVID-19. Conclusions: Vaccination against SARS-CoV-2 virus infection prevented the reduction of platelet mitochondrial respiration and energy production. The mechanism of suppression of CoQ(10) levels by SARS-CoV-2 virus is not fully known. Methods for the determination of CoQ(10) and HRR can be used for monitoring of mitochondrial bioenergetics and targeted therapy of patients with post-acute COVID-19. MDPI 2023-04-28 /pmc/articles/PMC10223181/ /pubmed/37243171 http://dx.doi.org/10.3390/v15051085 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gvozdjáková, Anna
Kucharská, Jarmila
Rausová, Zuzana
Lopéz-Lluch, Guillermo
Navas, Plácido
Palacka, Patrik
Bartolčičová, Barbora
Sumbalová, Zuzana
Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title_full Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title_fullStr Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title_full_unstemmed Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title_short Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
title_sort effect of vaccination on platelet mitochondrial bioenergy function of patients with post-acute covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223181/
https://www.ncbi.nlm.nih.gov/pubmed/37243171
http://dx.doi.org/10.3390/v15051085
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