Cargando…

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuce-Erarslan, Elif, Domb, Abraham (Avi) J., Kasem, Haytam, Uversky, Vladimir N., Coskuner-Weber, Orkid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223235/
https://www.ncbi.nlm.nih.gov/pubmed/37242981
http://dx.doi.org/10.3390/polym15102406
_version_ 1785049893223530496
author Yuce-Erarslan, Elif
Domb, Abraham (Avi) J.
Kasem, Haytam
Uversky, Vladimir N.
Coskuner-Weber, Orkid
author_facet Yuce-Erarslan, Elif
Domb, Abraham (Avi) J.
Kasem, Haytam
Uversky, Vladimir N.
Coskuner-Weber, Orkid
author_sort Yuce-Erarslan, Elif
collection PubMed
description In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins.
format Online
Article
Text
id pubmed-10223235
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102232352023-05-28 Intrinsically Disordered Synthetic Polymers in Biomedical Applications Yuce-Erarslan, Elif Domb, Abraham (Avi) J. Kasem, Haytam Uversky, Vladimir N. Coskuner-Weber, Orkid Polymers (Basel) Review In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking intrinsically disordered proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization and can be extremely useful in various biomedical applications. Among such applications, intrinsically disordered synthetic polymers can have potential usage in drug delivery, organ transplantation, artificial organ design, and immune compatibility. The designing of new syntheses and characterization mechanisms is currently required to provide the lacking intrinsically disordered synthetic polymers for biomedical applications bio-mimicked using intrinsically disordered proteins. Here, we present our strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on bio-mimicking intrinsically disordered proteins. MDPI 2023-05-22 /pmc/articles/PMC10223235/ /pubmed/37242981 http://dx.doi.org/10.3390/polym15102406 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yuce-Erarslan, Elif
Domb, Abraham (Avi) J.
Kasem, Haytam
Uversky, Vladimir N.
Coskuner-Weber, Orkid
Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title_full Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title_fullStr Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title_full_unstemmed Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title_short Intrinsically Disordered Synthetic Polymers in Biomedical Applications
title_sort intrinsically disordered synthetic polymers in biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223235/
https://www.ncbi.nlm.nih.gov/pubmed/37242981
http://dx.doi.org/10.3390/polym15102406
work_keys_str_mv AT yuceerarslanelif intrinsicallydisorderedsyntheticpolymersinbiomedicalapplications
AT dombabrahamavij intrinsicallydisorderedsyntheticpolymersinbiomedicalapplications
AT kasemhaytam intrinsicallydisorderedsyntheticpolymersinbiomedicalapplications
AT uverskyvladimirn intrinsicallydisorderedsyntheticpolymersinbiomedicalapplications
AT coskunerweberorkid intrinsicallydisorderedsyntheticpolymersinbiomedicalapplications