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Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls

The gut microbiome plays a significant role in regulating the host’s ability to store fat, which impacts the development of obesity. This observational cohort study recruited obese adult men and women scheduled to undergo sleeve gastrectomy and followed up with them 6 months post-surgery to analyse...

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Autores principales: Ahmad, Adilah F., Caparrós-Martín, Jose A., Lee, Silvia, O’Gara, Fergal, Yeap, Bu B., Green, Daniel J., Ballal, Mohammed, Ward, Natalie C., Dwivedi, Girish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223326/
https://www.ncbi.nlm.nih.gov/pubmed/37317100
http://dx.doi.org/10.3390/microorganisms11051126
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author Ahmad, Adilah F.
Caparrós-Martín, Jose A.
Lee, Silvia
O’Gara, Fergal
Yeap, Bu B.
Green, Daniel J.
Ballal, Mohammed
Ward, Natalie C.
Dwivedi, Girish
author_facet Ahmad, Adilah F.
Caparrós-Martín, Jose A.
Lee, Silvia
O’Gara, Fergal
Yeap, Bu B.
Green, Daniel J.
Ballal, Mohammed
Ward, Natalie C.
Dwivedi, Girish
author_sort Ahmad, Adilah F.
collection PubMed
description The gut microbiome plays a significant role in regulating the host’s ability to store fat, which impacts the development of obesity. This observational cohort study recruited obese adult men and women scheduled to undergo sleeve gastrectomy and followed up with them 6 months post-surgery to analyse their microbial taxonomic profiles and associated metabolites in comparison to a healthy control group. There were no significant differences in the gut bacterial diversity between the bariatric patients at baseline and at follow-up or between the bariatric patients and the cohort of healthy controls. However, there were differential abundances in specific bacterial groups between the two cohorts. The bariatric patients were observed to have significant enrichment in Granulicatella at baseline and Streptococcus and Actinomyces at follow-up compared to the healthy controls. Several operational taxonomic units assigned to commensal Clostridia were significantly reduced in the stool of bariatric patients both at baseline and follow-up. When compared to a healthy cohort, the plasma levels of the short chain fatty acid acetate were significantly higher in the bariatric surgery group at baseline. This remained significant when adjusted for age and sex (p = 0.013). The levels of soluble CD14 and CD163 were significantly higher (p = 0.0432 and p = 0.0067, respectively) in the bariatric surgery patients compared to the healthy controls at baseline. The present study demonstrated that there are alterations in the abundance of certain bacterial groups in the gut microbiome of obese patients prior to bariatric surgery compared to healthy individuals, which persist post-sleeve gastrectomy.
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spelling pubmed-102233262023-05-28 Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls Ahmad, Adilah F. Caparrós-Martín, Jose A. Lee, Silvia O’Gara, Fergal Yeap, Bu B. Green, Daniel J. Ballal, Mohammed Ward, Natalie C. Dwivedi, Girish Microorganisms Article The gut microbiome plays a significant role in regulating the host’s ability to store fat, which impacts the development of obesity. This observational cohort study recruited obese adult men and women scheduled to undergo sleeve gastrectomy and followed up with them 6 months post-surgery to analyse their microbial taxonomic profiles and associated metabolites in comparison to a healthy control group. There were no significant differences in the gut bacterial diversity between the bariatric patients at baseline and at follow-up or between the bariatric patients and the cohort of healthy controls. However, there were differential abundances in specific bacterial groups between the two cohorts. The bariatric patients were observed to have significant enrichment in Granulicatella at baseline and Streptococcus and Actinomyces at follow-up compared to the healthy controls. Several operational taxonomic units assigned to commensal Clostridia were significantly reduced in the stool of bariatric patients both at baseline and follow-up. When compared to a healthy cohort, the plasma levels of the short chain fatty acid acetate were significantly higher in the bariatric surgery group at baseline. This remained significant when adjusted for age and sex (p = 0.013). The levels of soluble CD14 and CD163 were significantly higher (p = 0.0432 and p = 0.0067, respectively) in the bariatric surgery patients compared to the healthy controls at baseline. The present study demonstrated that there are alterations in the abundance of certain bacterial groups in the gut microbiome of obese patients prior to bariatric surgery compared to healthy individuals, which persist post-sleeve gastrectomy. MDPI 2023-04-26 /pmc/articles/PMC10223326/ /pubmed/37317100 http://dx.doi.org/10.3390/microorganisms11051126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahmad, Adilah F.
Caparrós-Martín, Jose A.
Lee, Silvia
O’Gara, Fergal
Yeap, Bu B.
Green, Daniel J.
Ballal, Mohammed
Ward, Natalie C.
Dwivedi, Girish
Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title_full Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title_fullStr Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title_full_unstemmed Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title_short Gut Microbiome and Associated Metabolites Following Bariatric Surgery and Comparison to Healthy Controls
title_sort gut microbiome and associated metabolites following bariatric surgery and comparison to healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223326/
https://www.ncbi.nlm.nih.gov/pubmed/37317100
http://dx.doi.org/10.3390/microorganisms11051126
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