Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells

A new series of tetrasubstituted pyrrole derivatives (TSPs) was synthesized based on a previously developed hypothesis on their ability to mimic hydrophobic protein motifs. The resulting new TSPs were endowed with a significant toxicity against human epithelial melanoma A375 cells, showing IC(50) va...

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Detalles Bibliográficos
Autores principales: Persico, Marco, Galatello, Paola, Ferraro, Maria Grazia, Irace, Carlo, Piccolo, Marialuisa, Abduvakhidov, Avazbek, Tkachuk, Oleh, d’Aulisio Garigliota, Maria Luisa, Campiglia, Pietro, Iannece, Patrizia, Varra, Michela, Ramunno, Anna, Fattorusso, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223356/
https://www.ncbi.nlm.nih.gov/pubmed/37241902
http://dx.doi.org/10.3390/molecules28104161

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