Cargando…

Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein

Canocapavir is a novel antiviral agent with characteristics of core protein allosteric modulators (CpAMs) that is currently in a phase II clinical trial for treatment of hepatitis B virus (HBV) infection. Herein, we show that Canocapavir prevented the encapsidation of HBV pregenomic RNA and increase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Yuan, Yang, Le, Yu, Lin, Zhu, Yuanfei, Wu, Yang, Zhang, Zhijun, Xia, Tian, Deng, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223407/ https://www.ncbi.nlm.nih.gov/pubmed/37243280 http://dx.doi.org/10.3390/v15051195

Ejemplares similares

Targeting the HIV-1 and HBV Capsids, an EnCore
por: McFadden, William M., et al.
Publicado: (2023)

Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial
por: Jia, Haiyan, et al.
Publicado: (2023)

Allosteric conformational changes of human HBV core protein transform its assembly
por: Liu, Chuang, et al.
Publicado: (2017)

Capsid Assembly Modulators as Antiviral Agents against HBV: Molecular Mechanisms and Clinical Perspectives
por: Taverniti, Valerio, et al.
Publicado: (2022)

Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication
por: Yang, Yang, et al.
Publicado: (2022)

Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection
por: Zhang, Hong, et al.
Publicado: (2020)

Biophysical Characterization of the Feline Immunodeficiency Virus p24 Capsid Protein Conformation and In Vitro Capsid Assembly
por: Serrière, Jennifer, et al.
Publicado: (2013)

Universal linker-free assembly of core–satellite hetero-superstructures
por: Hu, Yanfang, et al.
Publicado: (2022)

Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
por: Spunde, Karina, et al.
Publicado: (2022)

The Hepatitis B Virus Core Protein Intradimer Interface Modulates Capsid Assembly and Stability
por: Selzer, Lisa, et al.
Publicado: (2014)

Mutation in the Disordered Linker Region of Capsid Disrupts Viral Kinetics of a Neuropathogenic SIV in Rhesus Macaques
por: Lee, Cheri A., et al.
Publicado: (2022)

The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90
por: López, Abraham, et al.
Publicado: (2020)

Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket
por: Briday, Mathilde, et al.
Publicado: (2022)

Evans Blue Inhibits HBV Replication Through a Dual Antiviral Mechanism by Targeting Virus Binding and Capsid Assembly
por: Xiao, Yu, et al.
Publicado: (2019)

Adeno-associated virus capsid protein expression in Escherichia coli and chemically defined capsid assembly
por: Le, Dinh To, et al.
Publicado: (2019)

Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria
por: Chen, Yuwan, et al.
Publicado: (2023)

Quantum dot-induced viral capsid assembling in dissociation buffer
por: Gao, Ding, et al.
Publicado: (2013)

Atomic Structure of the Human Sapovirus Capsid Reveals a Unique Capsid Protein Conformation in Caliciviruses
por: Miyazaki, Naoyuki, et al.
Publicado: (2022)

Rotten to the core: antivirals targeting the HIV-1 capsid core
por: McFadden, William M., et al.
Publicado: (2021)

The Origin of Capsid-Derived Immune Complexes and Their Impact on HBV-Induced Liver Diseases
por: Zhang, Xiaonan, et al.
Publicado: (2022)

HBV Core Protein Enhances Cytokine Production
por: Kanda, Tatsuo, et al.
Publicado: (2015)

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
por: Borst, Eva Maria, et al.
Publicado: (2022)

Electrostatic repulsion regulates hiv-1 capsid hexamer plasticity and assembling capacities into core-like structures
por: Brun, Sonia, et al.
Publicado: (2009)

Bluetongue Virus Capsid Assembly and Maturation
por: Mohl, Bjorn-Patrick, et al.
Publicado: (2014)

The Dynamics of Viruslike Capsid Assembly and Disassembly
por: Timmermans, Suzanne B. P. E., et al.
Publicado: (2022)

Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly
por: Viney, Lydia, et al.
Publicado: (2021)

Regulation of chromatin folding by conformational variations of nucleosome linker DNA
por: Buckwalter, Jenna M., et al.
Publicado: (2017)

Linker-mediated self-assembly of mobile DNA-coated colloids
por: Xia, Xiuyang, et al.
Publicado: (2020)

The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion
por: Chou, Shu-Fan, et al.
Publicado: (2015)

Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection
por: Janssen, Harry L A, et al.
Publicado: (2023)

Conformational Dynamics of Nonenveloped Circovirus Capsid to the Host Cell Receptor
por: Li, Jiarong, et al.
Publicado: (2020)

Bacteriophage MS2 displays unreported capsid variability assembling T = 4 and mixed capsids
por: de Martín Garrido, Natàlia, et al.
Publicado: (2019)

Linker Histone in Diseases
por: Ye, Xin, et al.
Publicado: (2017)

Viral genome structures are optimal for capsid assembly
por: Perlmutter, Jason D, et al.
Publicado: (2013)

Self-assembly of model proteins into virus capsids
por: Wołek, Karol, et al.
Publicado: (2017)

Conformational selection and dynamic adaptation upon linker histone binding to the nucleosome
por: Öztürk, Mehmet Ali, et al.
Publicado: (2016)

Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states
por: Tan, Dan, et al.
Publicado: (2016)

Traceless Photolabile Linker Expedites the Chemical Synthesis of Complex Oligosaccharides by Automated Glycan Assembly
por: Le Mai Hoang, Kim, et al.
Publicado: (2019)

A Kinase Chaperones Hepatitis B Virus Capsid Assembly and Captures Capsid Dynamics in vitro
por: Chen, Chao, et al.
Publicado: (2011)

Inhibition of the HCV Core Protein on the Immune Response to HBV Surface Antigen and on HBV Gene Expression and Replication In Vivo
por: Zhu, Wenbo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8v4r2sitp922881mfno5sp1oh0