Cargando…

Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017

Dengue has been one of the major public health concerns in the Philippines for more than a century. The annual dengue case burden has been increasing in recent years, exceeding 200,000 in 2015 and 2019. However, there is limited information on the molecular epidemiology of dengue in the Philippines....

Descripción completa

Detalles Bibliográficos
Autores principales: Sy, Ava Kristy, Koo, Carmen, Privaldos, Kristine J. R., Quinones, Mary Ann T., Igoy, Mary A. U., Villanueva, Sharon Y. A. M., Hibberd, Martin L., Ng, Lee Ching, Hapuarachchi, Hapuarachchige C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223597/
https://www.ncbi.nlm.nih.gov/pubmed/37243165
http://dx.doi.org/10.3390/v15051079
_version_ 1785049979822276608
author Sy, Ava Kristy
Koo, Carmen
Privaldos, Kristine J. R.
Quinones, Mary Ann T.
Igoy, Mary A. U.
Villanueva, Sharon Y. A. M.
Hibberd, Martin L.
Ng, Lee Ching
Hapuarachchi, Hapuarachchige C.
author_facet Sy, Ava Kristy
Koo, Carmen
Privaldos, Kristine J. R.
Quinones, Mary Ann T.
Igoy, Mary A. U.
Villanueva, Sharon Y. A. M.
Hibberd, Martin L.
Ng, Lee Ching
Hapuarachchi, Hapuarachchige C.
author_sort Sy, Ava Kristy
collection PubMed
description Dengue has been one of the major public health concerns in the Philippines for more than a century. The annual dengue case burden has been increasing in recent years, exceeding 200,000 in 2015 and 2019. However, there is limited information on the molecular epidemiology of dengue in the Philippines. We, therefore, conducted a study to understand the genetic composition and dispersal of DENV in the Philippines from 2015 to 2017 under UNITEDengue. Our analyses included 377 envelope (E) gene sequences of all 4 serotypes obtained from infections in 3 main island groups (Luzon, Visayas, and Mindanao) of the Philippines. The findings showed that the overall diversity of DENV was generally low. DENV-1 was relatively more diverse than the other serotypes. Virus dispersal was evident among the three main island groups, but each island group demonstrated a distinct genotype composition. These observations suggested that the intensity of virus dispersal was not substantive enough to maintain a uniform heterogeneity among island groups so that each island group behaved as an independent epidemiological unit. The analyses suggested Luzon as one of the major sources of DENV emergence and CAR, Calabarzon, and CARAGA as important hubs of virus dispersal in the Philippines. Our findings highlight the importance of virus surveillance and molecular epidemiological analyses to gain deep insights into virus diversity, lineage dominance, and dispersal patterns that could assist in understanding the epidemiology and transmission risk of dengue in endemic regions.
format Online
Article
Text
id pubmed-10223597
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102235972023-05-28 Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017 Sy, Ava Kristy Koo, Carmen Privaldos, Kristine J. R. Quinones, Mary Ann T. Igoy, Mary A. U. Villanueva, Sharon Y. A. M. Hibberd, Martin L. Ng, Lee Ching Hapuarachchi, Hapuarachchige C. Viruses Article Dengue has been one of the major public health concerns in the Philippines for more than a century. The annual dengue case burden has been increasing in recent years, exceeding 200,000 in 2015 and 2019. However, there is limited information on the molecular epidemiology of dengue in the Philippines. We, therefore, conducted a study to understand the genetic composition and dispersal of DENV in the Philippines from 2015 to 2017 under UNITEDengue. Our analyses included 377 envelope (E) gene sequences of all 4 serotypes obtained from infections in 3 main island groups (Luzon, Visayas, and Mindanao) of the Philippines. The findings showed that the overall diversity of DENV was generally low. DENV-1 was relatively more diverse than the other serotypes. Virus dispersal was evident among the three main island groups, but each island group demonstrated a distinct genotype composition. These observations suggested that the intensity of virus dispersal was not substantive enough to maintain a uniform heterogeneity among island groups so that each island group behaved as an independent epidemiological unit. The analyses suggested Luzon as one of the major sources of DENV emergence and CAR, Calabarzon, and CARAGA as important hubs of virus dispersal in the Philippines. Our findings highlight the importance of virus surveillance and molecular epidemiological analyses to gain deep insights into virus diversity, lineage dominance, and dispersal patterns that could assist in understanding the epidemiology and transmission risk of dengue in endemic regions. MDPI 2023-04-28 /pmc/articles/PMC10223597/ /pubmed/37243165 http://dx.doi.org/10.3390/v15051079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sy, Ava Kristy
Koo, Carmen
Privaldos, Kristine J. R.
Quinones, Mary Ann T.
Igoy, Mary A. U.
Villanueva, Sharon Y. A. M.
Hibberd, Martin L.
Ng, Lee Ching
Hapuarachchi, Hapuarachchige C.
Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title_full Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title_fullStr Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title_full_unstemmed Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title_short Genetic Diversity and Dispersal of DENGUE Virus among Three Main Island Groups of the Philippines during 2015–2017
title_sort genetic diversity and dispersal of dengue virus among three main island groups of the philippines during 2015–2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223597/
https://www.ncbi.nlm.nih.gov/pubmed/37243165
http://dx.doi.org/10.3390/v15051079
work_keys_str_mv AT syavakristy geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT koocarmen geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT privaldoskristinejr geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT quinonesmaryannt geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT igoymaryau geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT villanuevasharonyam geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT hibberdmartinl geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT ngleeching geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017
AT hapuarachchihapuarachchigec geneticdiversityanddispersalofdenguevirusamongthreemainislandgroupsofthephilippinesduring20152017