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Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection

Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associ...

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Autores principales: Vojtková, Jarmila, Bánovčin, Peter, Ďurdíková, Anna, Nováková, Elena, Jeseňák, Miloš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223621/
https://www.ncbi.nlm.nih.gov/pubmed/37241176
http://dx.doi.org/10.3390/medicina59050944
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author Vojtková, Jarmila
Bánovčin, Peter
Ďurdíková, Anna
Nováková, Elena
Jeseňák, Miloš
author_facet Vojtková, Jarmila
Bánovčin, Peter
Ďurdíková, Anna
Nováková, Elena
Jeseňák, Miloš
author_sort Vojtková, Jarmila
collection PubMed
description Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associated with hyperglycaemia. Materials and Methods: A total of 235 children were enrolled in the study between October 2021 and October 2022, 112 with confirmed COVID-19 infection and 123 with other RNA viral infection. In all patients, types of symptoms, glycaemia at the time of admission, and basic anthropometric and biochemical parameters were recorded. Results: Average glycaemia was significantly higher in COVID-19 patients compared to other viral infections (5.7 ± 1.12 vs. 5.31 ± 1.4 mmol/L, p = 0.011). This difference was more obvious in subgroups with gastrointestinal manifestations (5.6 ± 1.11 vs. 4.81 ± 1.38 mmol/L, p = 0.0006) and with fever (5.76±1.22 vs. 5.11±1.37 mmol/L, p = 0.002), while no significant difference was found in subgroups with mainly respiratory symptoms. The risk of hyperglycaemia (>5.6 mmol/L) was higher in COVID-19 patients compared to other viral infections (OR = 1.86, 95%CI = 1.10–3.14, p = 0.02). The risk of hyperglycaemia was significantly higher in COVID-19 compared to other viral infections in the subgroups of patients with fever (OR = 3.59, 95% CI 1.755–7.345, p = 0.0005) and with gastrointestinal manifestations (OR = 2.48, 95% CI 1.058–5.791, p = 0.036). Conclusion: According to our results, mild hyperglycaemia was significantly more common in children with moderate COVID-19 infection compared to other RNA virus respiratory and gastrointestinal infections, especially when accompanied by fever or gastrointestinal symptoms.
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spelling pubmed-102236212023-05-28 Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection Vojtková, Jarmila Bánovčin, Peter Ďurdíková, Anna Nováková, Elena Jeseňák, Miloš Medicina (Kaunas) Article Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associated with hyperglycaemia. Materials and Methods: A total of 235 children were enrolled in the study between October 2021 and October 2022, 112 with confirmed COVID-19 infection and 123 with other RNA viral infection. In all patients, types of symptoms, glycaemia at the time of admission, and basic anthropometric and biochemical parameters were recorded. Results: Average glycaemia was significantly higher in COVID-19 patients compared to other viral infections (5.7 ± 1.12 vs. 5.31 ± 1.4 mmol/L, p = 0.011). This difference was more obvious in subgroups with gastrointestinal manifestations (5.6 ± 1.11 vs. 4.81 ± 1.38 mmol/L, p = 0.0006) and with fever (5.76±1.22 vs. 5.11±1.37 mmol/L, p = 0.002), while no significant difference was found in subgroups with mainly respiratory symptoms. The risk of hyperglycaemia (>5.6 mmol/L) was higher in COVID-19 patients compared to other viral infections (OR = 1.86, 95%CI = 1.10–3.14, p = 0.02). The risk of hyperglycaemia was significantly higher in COVID-19 compared to other viral infections in the subgroups of patients with fever (OR = 3.59, 95% CI 1.755–7.345, p = 0.0005) and with gastrointestinal manifestations (OR = 2.48, 95% CI 1.058–5.791, p = 0.036). Conclusion: According to our results, mild hyperglycaemia was significantly more common in children with moderate COVID-19 infection compared to other RNA virus respiratory and gastrointestinal infections, especially when accompanied by fever or gastrointestinal symptoms. MDPI 2023-05-14 /pmc/articles/PMC10223621/ /pubmed/37241176 http://dx.doi.org/10.3390/medicina59050944 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vojtková, Jarmila
Bánovčin, Peter
Ďurdíková, Anna
Nováková, Elena
Jeseňák, Miloš
Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title_full Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title_fullStr Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title_full_unstemmed Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title_short Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
title_sort mild hyperglycaemia in hospitalised children with moderate covid-19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223621/
https://www.ncbi.nlm.nih.gov/pubmed/37241176
http://dx.doi.org/10.3390/medicina59050944
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