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Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection
Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223621/ https://www.ncbi.nlm.nih.gov/pubmed/37241176 http://dx.doi.org/10.3390/medicina59050944 |
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author | Vojtková, Jarmila Bánovčin, Peter Ďurdíková, Anna Nováková, Elena Jeseňák, Miloš |
author_facet | Vojtková, Jarmila Bánovčin, Peter Ďurdíková, Anna Nováková, Elena Jeseňák, Miloš |
author_sort | Vojtková, Jarmila |
collection | PubMed |
description | Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associated with hyperglycaemia. Materials and Methods: A total of 235 children were enrolled in the study between October 2021 and October 2022, 112 with confirmed COVID-19 infection and 123 with other RNA viral infection. In all patients, types of symptoms, glycaemia at the time of admission, and basic anthropometric and biochemical parameters were recorded. Results: Average glycaemia was significantly higher in COVID-19 patients compared to other viral infections (5.7 ± 1.12 vs. 5.31 ± 1.4 mmol/L, p = 0.011). This difference was more obvious in subgroups with gastrointestinal manifestations (5.6 ± 1.11 vs. 4.81 ± 1.38 mmol/L, p = 0.0006) and with fever (5.76±1.22 vs. 5.11±1.37 mmol/L, p = 0.002), while no significant difference was found in subgroups with mainly respiratory symptoms. The risk of hyperglycaemia (>5.6 mmol/L) was higher in COVID-19 patients compared to other viral infections (OR = 1.86, 95%CI = 1.10–3.14, p = 0.02). The risk of hyperglycaemia was significantly higher in COVID-19 compared to other viral infections in the subgroups of patients with fever (OR = 3.59, 95% CI 1.755–7.345, p = 0.0005) and with gastrointestinal manifestations (OR = 2.48, 95% CI 1.058–5.791, p = 0.036). Conclusion: According to our results, mild hyperglycaemia was significantly more common in children with moderate COVID-19 infection compared to other RNA virus respiratory and gastrointestinal infections, especially when accompanied by fever or gastrointestinal symptoms. |
format | Online Article Text |
id | pubmed-10223621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102236212023-05-28 Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection Vojtková, Jarmila Bánovčin, Peter Ďurdíková, Anna Nováková, Elena Jeseňák, Miloš Medicina (Kaunas) Article Background and Objectives: COVID-19 infection may influence many physiological processes, including glucose metabolism. Acute hyperglycaemia has been related to a worse prognosis in patients with severe COVID-19 infection. The aim of our study was to find out if moderate COVID-19 infection is associated with hyperglycaemia. Materials and Methods: A total of 235 children were enrolled in the study between October 2021 and October 2022, 112 with confirmed COVID-19 infection and 123 with other RNA viral infection. In all patients, types of symptoms, glycaemia at the time of admission, and basic anthropometric and biochemical parameters were recorded. Results: Average glycaemia was significantly higher in COVID-19 patients compared to other viral infections (5.7 ± 1.12 vs. 5.31 ± 1.4 mmol/L, p = 0.011). This difference was more obvious in subgroups with gastrointestinal manifestations (5.6 ± 1.11 vs. 4.81 ± 1.38 mmol/L, p = 0.0006) and with fever (5.76±1.22 vs. 5.11±1.37 mmol/L, p = 0.002), while no significant difference was found in subgroups with mainly respiratory symptoms. The risk of hyperglycaemia (>5.6 mmol/L) was higher in COVID-19 patients compared to other viral infections (OR = 1.86, 95%CI = 1.10–3.14, p = 0.02). The risk of hyperglycaemia was significantly higher in COVID-19 compared to other viral infections in the subgroups of patients with fever (OR = 3.59, 95% CI 1.755–7.345, p = 0.0005) and with gastrointestinal manifestations (OR = 2.48, 95% CI 1.058–5.791, p = 0.036). Conclusion: According to our results, mild hyperglycaemia was significantly more common in children with moderate COVID-19 infection compared to other RNA virus respiratory and gastrointestinal infections, especially when accompanied by fever or gastrointestinal symptoms. MDPI 2023-05-14 /pmc/articles/PMC10223621/ /pubmed/37241176 http://dx.doi.org/10.3390/medicina59050944 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vojtková, Jarmila Bánovčin, Peter Ďurdíková, Anna Nováková, Elena Jeseňák, Miloš Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title | Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title_full | Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title_fullStr | Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title_full_unstemmed | Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title_short | Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection |
title_sort | mild hyperglycaemia in hospitalised children with moderate covid-19 infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223621/ https://www.ncbi.nlm.nih.gov/pubmed/37241176 http://dx.doi.org/10.3390/medicina59050944 |
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