Cargando…

Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions

Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impair...

Descripción completa

Detalles Bibliográficos
Autores principales: Klawitter, Felix, Walter, Uwe, Axer, Hubertus, Patejdl, Robert, Ehler, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223702/
https://www.ncbi.nlm.nih.gov/pubmed/37241077
http://dx.doi.org/10.3390/medicina59050844
_version_ 1785050004635779072
author Klawitter, Felix
Walter, Uwe
Axer, Hubertus
Patejdl, Robert
Ehler, Johannes
author_facet Klawitter, Felix
Walter, Uwe
Axer, Hubertus
Patejdl, Robert
Ehler, Johannes
author_sort Klawitter, Felix
collection PubMed
description Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to evaluate alternative compliance-independent methods, such as muscle biopsies, nerve conduction studies, electromyography and serum biomarkers. However, they are invasive, time-consuming and often require special expertise to perform, making them vastly impractical for daily intensive care medicine. Ultrasound is a broadly accepted, non-invasive, bedside-accessible diagnostic tool and well established in various clinical applications. Hereby, neuromuscular ultrasound (NMUS), in particular, has been proven to be of significant diagnostic value in many different neuromuscular diseases. In ICUAW, NMUS has been shown to detect and monitor alterations of muscles and nerves, and might help to predict patient outcome. This narrative review is focused on the recent scientific literature investigating NMUS in ICUAW and highlights the current state and future opportunities of this promising diagnostic tool.
format Online
Article
Text
id pubmed-10223702
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102237022023-05-28 Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions Klawitter, Felix Walter, Uwe Axer, Hubertus Patejdl, Robert Ehler, Johannes Medicina (Kaunas) Review Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to evaluate alternative compliance-independent methods, such as muscle biopsies, nerve conduction studies, electromyography and serum biomarkers. However, they are invasive, time-consuming and often require special expertise to perform, making them vastly impractical for daily intensive care medicine. Ultrasound is a broadly accepted, non-invasive, bedside-accessible diagnostic tool and well established in various clinical applications. Hereby, neuromuscular ultrasound (NMUS), in particular, has been proven to be of significant diagnostic value in many different neuromuscular diseases. In ICUAW, NMUS has been shown to detect and monitor alterations of muscles and nerves, and might help to predict patient outcome. This narrative review is focused on the recent scientific literature investigating NMUS in ICUAW and highlights the current state and future opportunities of this promising diagnostic tool. MDPI 2023-04-27 /pmc/articles/PMC10223702/ /pubmed/37241077 http://dx.doi.org/10.3390/medicina59050844 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Klawitter, Felix
Walter, Uwe
Axer, Hubertus
Patejdl, Robert
Ehler, Johannes
Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title_full Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title_fullStr Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title_full_unstemmed Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title_short Neuromuscular Ultrasound in Intensive Care Unit-Acquired Weakness: Current State and Future Directions
title_sort neuromuscular ultrasound in intensive care unit-acquired weakness: current state and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223702/
https://www.ncbi.nlm.nih.gov/pubmed/37241077
http://dx.doi.org/10.3390/medicina59050844
work_keys_str_mv AT klawitterfelix neuromuscularultrasoundinintensivecareunitacquiredweaknesscurrentstateandfuturedirections
AT walteruwe neuromuscularultrasoundinintensivecareunitacquiredweaknesscurrentstateandfuturedirections
AT axerhubertus neuromuscularultrasoundinintensivecareunitacquiredweaknesscurrentstateandfuturedirections
AT patejdlrobert neuromuscularultrasoundinintensivecareunitacquiredweaknesscurrentstateandfuturedirections
AT ehlerjohannes neuromuscularultrasoundinintensivecareunitacquiredweaknesscurrentstateandfuturedirections