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Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer

Background: This retrospective single-center cohort study evaluated the efficacy and safety of a combination of neoadjuvant luteinizing hormone-releasing hormone (LHRH) antagonist and tegafur-uracil (UFT) therapy (NCHT) and investigated the medical records of patients with high-risk PCa who underwen...

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Autores principales: Sugino, Fumiya, Nakane, Keita, Kawase, Makoto, Ueda, Shota, Tomioka, Masayuki, Takeuchi, Yasumichi, Tomioka-Inagawa, Risa, Yamada, Toyohiro, Namiki, Sanae, Kumada, Naotaka, Takeuchi, Shinichi, Kawase, Kota, Kato, Daiki, Takai, Manabu, Iinuma, Koji, Tobisawa, Yuki, Koie, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223720/
https://www.ncbi.nlm.nih.gov/pubmed/37240717
http://dx.doi.org/10.3390/life13051072
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author Sugino, Fumiya
Nakane, Keita
Kawase, Makoto
Ueda, Shota
Tomioka, Masayuki
Takeuchi, Yasumichi
Tomioka-Inagawa, Risa
Yamada, Toyohiro
Namiki, Sanae
Kumada, Naotaka
Takeuchi, Shinichi
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Tobisawa, Yuki
Koie, Takuya
author_facet Sugino, Fumiya
Nakane, Keita
Kawase, Makoto
Ueda, Shota
Tomioka, Masayuki
Takeuchi, Yasumichi
Tomioka-Inagawa, Risa
Yamada, Toyohiro
Namiki, Sanae
Kumada, Naotaka
Takeuchi, Shinichi
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Tobisawa, Yuki
Koie, Takuya
author_sort Sugino, Fumiya
collection PubMed
description Background: This retrospective single-center cohort study evaluated the efficacy and safety of a combination of neoadjuvant luteinizing hormone-releasing hormone (LHRH) antagonist and tegafur-uracil (UFT) therapy (NCHT) and investigated the medical records of patients with high-risk PCa who underwent robot-assisted radical prostatectomy (RARP). The therapy was followed by RARP for high-risk PCa. Materials and Methods: The enrolled patients were divided into two groups: low-intermediate-risk PCa patients who underwent RARP without neoadjuvant therapy (non-high-risk) and those who underwent NCHT followed by RARP (high-risk group). This study enrolled 227 patients (126: non-high-risk and 101: high-risk group). Patients in the high-risk-group had high-grade cancer compared to those in the non-high-risk-group. Results: At the median follow-up period of 12.0 months, there were no PCa deaths; two patients (0.9%) died of other causes. Twenty patients developed biochemical recurrence (BCR); the median time until BCR was 9.9 months after surgery. The 2-year biochemical recurrence-free survival rates were 94.2% and 91.1% in the non-high-risk and high-risk-group, respectively (p = 0.465). Grade ≥3 NCHT-related adverse events developed in nine patients (8.9%). Conclusions: This study indicates that combining neoadjuvant LHRH antagonists and UFT followed by RARP may improve oncological outcomes in patients with high-risk PCa.
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spelling pubmed-102237202023-05-28 Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer Sugino, Fumiya Nakane, Keita Kawase, Makoto Ueda, Shota Tomioka, Masayuki Takeuchi, Yasumichi Tomioka-Inagawa, Risa Yamada, Toyohiro Namiki, Sanae Kumada, Naotaka Takeuchi, Shinichi Kawase, Kota Kato, Daiki Takai, Manabu Iinuma, Koji Tobisawa, Yuki Koie, Takuya Life (Basel) Article Background: This retrospective single-center cohort study evaluated the efficacy and safety of a combination of neoadjuvant luteinizing hormone-releasing hormone (LHRH) antagonist and tegafur-uracil (UFT) therapy (NCHT) and investigated the medical records of patients with high-risk PCa who underwent robot-assisted radical prostatectomy (RARP). The therapy was followed by RARP for high-risk PCa. Materials and Methods: The enrolled patients were divided into two groups: low-intermediate-risk PCa patients who underwent RARP without neoadjuvant therapy (non-high-risk) and those who underwent NCHT followed by RARP (high-risk group). This study enrolled 227 patients (126: non-high-risk and 101: high-risk group). Patients in the high-risk-group had high-grade cancer compared to those in the non-high-risk-group. Results: At the median follow-up period of 12.0 months, there were no PCa deaths; two patients (0.9%) died of other causes. Twenty patients developed biochemical recurrence (BCR); the median time until BCR was 9.9 months after surgery. The 2-year biochemical recurrence-free survival rates were 94.2% and 91.1% in the non-high-risk and high-risk-group, respectively (p = 0.465). Grade ≥3 NCHT-related adverse events developed in nine patients (8.9%). Conclusions: This study indicates that combining neoadjuvant LHRH antagonists and UFT followed by RARP may improve oncological outcomes in patients with high-risk PCa. MDPI 2023-04-23 /pmc/articles/PMC10223720/ /pubmed/37240717 http://dx.doi.org/10.3390/life13051072 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sugino, Fumiya
Nakane, Keita
Kawase, Makoto
Ueda, Shota
Tomioka, Masayuki
Takeuchi, Yasumichi
Tomioka-Inagawa, Risa
Yamada, Toyohiro
Namiki, Sanae
Kumada, Naotaka
Takeuchi, Shinichi
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Tobisawa, Yuki
Koie, Takuya
Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title_full Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title_fullStr Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title_full_unstemmed Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title_short Efficacy and Safety of Neoadjuvant Luteinizing Hormone-Releasing Hormone Antagonist and Tegafur-Uracil Chemohormonal Therapy for High-Risk Prostate Cancer
title_sort efficacy and safety of neoadjuvant luteinizing hormone-releasing hormone antagonist and tegafur-uracil chemohormonal therapy for high-risk prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223720/
https://www.ncbi.nlm.nih.gov/pubmed/37240717
http://dx.doi.org/10.3390/life13051072
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