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The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience

Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study po...

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Autores principales: Zotou, Paraskevi, Bechlioulis, Aris, Tsiouris, Spyridon, Naka, Katerina K., Xourgia, Xanthi, Pappas, Konstantinos, Lakkas, Lampros, Rammos, Aidonis, Kalef-Ezra, John, Michalis, Lampros K., Fotopoulos, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223725/
https://www.ncbi.nlm.nih.gov/pubmed/37241041
http://dx.doi.org/10.3390/jpm13050871
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author Zotou, Paraskevi
Bechlioulis, Aris
Tsiouris, Spyridon
Naka, Katerina K.
Xourgia, Xanthi
Pappas, Konstantinos
Lakkas, Lampros
Rammos, Aidonis
Kalef-Ezra, John
Michalis, Lampros K.
Fotopoulos, Andreas
author_facet Zotou, Paraskevi
Bechlioulis, Aris
Tsiouris, Spyridon
Naka, Katerina K.
Xourgia, Xanthi
Pappas, Konstantinos
Lakkas, Lampros
Rammos, Aidonis
Kalef-Ezra, John
Michalis, Lampros K.
Fotopoulos, Andreas
author_sort Zotou, Paraskevi
collection PubMed
description Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study population was composed of 614 consecutive patients (mean age: 67 years, 55% male) referred for SPECT MPI due to symptoms of stable CAD. The SPECT MPI was performed using a single-day protocol. We conducted a follow-up on all patients at 12 months via a telephone interview. Results: The majority of our patients (78%) presented findings suggestive of reversible ischemia, fixed defects or both. Extensive perfusion defects were found in 18% of the population, while LV dilation was found in 7%. During the 12-month follow-up, 16 deaths, 8 non-fatal MIs and 20 non-fatal strokes were recorded. There was no significant association of SPECT findings with the combined endpoint of all-cause death, non-fatal MI and non-fatal stroke. The presence of extensive perfusion defects was an independent predictor of mortality at 12 months (HR: 2.90, 95% CI: 1.05, 8.06, p = 0.041). Conclusions: In a high-risk patient population with suspected stable CAD, only large reversible perfusion defects in SPECT MPI were independently associated with mortality at 1 year. Further trials are needed to validate our findings and refine the role of SPECT MPI findings in the diagnosis and prognosis of cardiovascular patients.
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spelling pubmed-102237252023-05-28 The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience Zotou, Paraskevi Bechlioulis, Aris Tsiouris, Spyridon Naka, Katerina K. Xourgia, Xanthi Pappas, Konstantinos Lakkas, Lampros Rammos, Aidonis Kalef-Ezra, John Michalis, Lampros K. Fotopoulos, Andreas J Pers Med Brief Report Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study population was composed of 614 consecutive patients (mean age: 67 years, 55% male) referred for SPECT MPI due to symptoms of stable CAD. The SPECT MPI was performed using a single-day protocol. We conducted a follow-up on all patients at 12 months via a telephone interview. Results: The majority of our patients (78%) presented findings suggestive of reversible ischemia, fixed defects or both. Extensive perfusion defects were found in 18% of the population, while LV dilation was found in 7%. During the 12-month follow-up, 16 deaths, 8 non-fatal MIs and 20 non-fatal strokes were recorded. There was no significant association of SPECT findings with the combined endpoint of all-cause death, non-fatal MI and non-fatal stroke. The presence of extensive perfusion defects was an independent predictor of mortality at 12 months (HR: 2.90, 95% CI: 1.05, 8.06, p = 0.041). Conclusions: In a high-risk patient population with suspected stable CAD, only large reversible perfusion defects in SPECT MPI were independently associated with mortality at 1 year. Further trials are needed to validate our findings and refine the role of SPECT MPI findings in the diagnosis and prognosis of cardiovascular patients. MDPI 2023-05-22 /pmc/articles/PMC10223725/ /pubmed/37241041 http://dx.doi.org/10.3390/jpm13050871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Zotou, Paraskevi
Bechlioulis, Aris
Tsiouris, Spyridon
Naka, Katerina K.
Xourgia, Xanthi
Pappas, Konstantinos
Lakkas, Lampros
Rammos, Aidonis
Kalef-Ezra, John
Michalis, Lampros K.
Fotopoulos, Andreas
The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title_full The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title_fullStr The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title_full_unstemmed The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title_short The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
title_sort role of myocardial perfusion imaging in the prediction of major adverse cardiovascular events at 1 year follow-up: a single center’s experience
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223725/
https://www.ncbi.nlm.nih.gov/pubmed/37241041
http://dx.doi.org/10.3390/jpm13050871
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