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The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience
Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study po...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223725/ https://www.ncbi.nlm.nih.gov/pubmed/37241041 http://dx.doi.org/10.3390/jpm13050871 |
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author | Zotou, Paraskevi Bechlioulis, Aris Tsiouris, Spyridon Naka, Katerina K. Xourgia, Xanthi Pappas, Konstantinos Lakkas, Lampros Rammos, Aidonis Kalef-Ezra, John Michalis, Lampros K. Fotopoulos, Andreas |
author_facet | Zotou, Paraskevi Bechlioulis, Aris Tsiouris, Spyridon Naka, Katerina K. Xourgia, Xanthi Pappas, Konstantinos Lakkas, Lampros Rammos, Aidonis Kalef-Ezra, John Michalis, Lampros K. Fotopoulos, Andreas |
author_sort | Zotou, Paraskevi |
collection | PubMed |
description | Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study population was composed of 614 consecutive patients (mean age: 67 years, 55% male) referred for SPECT MPI due to symptoms of stable CAD. The SPECT MPI was performed using a single-day protocol. We conducted a follow-up on all patients at 12 months via a telephone interview. Results: The majority of our patients (78%) presented findings suggestive of reversible ischemia, fixed defects or both. Extensive perfusion defects were found in 18% of the population, while LV dilation was found in 7%. During the 12-month follow-up, 16 deaths, 8 non-fatal MIs and 20 non-fatal strokes were recorded. There was no significant association of SPECT findings with the combined endpoint of all-cause death, non-fatal MI and non-fatal stroke. The presence of extensive perfusion defects was an independent predictor of mortality at 12 months (HR: 2.90, 95% CI: 1.05, 8.06, p = 0.041). Conclusions: In a high-risk patient population with suspected stable CAD, only large reversible perfusion defects in SPECT MPI were independently associated with mortality at 1 year. Further trials are needed to validate our findings and refine the role of SPECT MPI findings in the diagnosis and prognosis of cardiovascular patients. |
format | Online Article Text |
id | pubmed-10223725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102237252023-05-28 The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience Zotou, Paraskevi Bechlioulis, Aris Tsiouris, Spyridon Naka, Katerina K. Xourgia, Xanthi Pappas, Konstantinos Lakkas, Lampros Rammos, Aidonis Kalef-Ezra, John Michalis, Lampros K. Fotopoulos, Andreas J Pers Med Brief Report Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study population was composed of 614 consecutive patients (mean age: 67 years, 55% male) referred for SPECT MPI due to symptoms of stable CAD. The SPECT MPI was performed using a single-day protocol. We conducted a follow-up on all patients at 12 months via a telephone interview. Results: The majority of our patients (78%) presented findings suggestive of reversible ischemia, fixed defects or both. Extensive perfusion defects were found in 18% of the population, while LV dilation was found in 7%. During the 12-month follow-up, 16 deaths, 8 non-fatal MIs and 20 non-fatal strokes were recorded. There was no significant association of SPECT findings with the combined endpoint of all-cause death, non-fatal MI and non-fatal stroke. The presence of extensive perfusion defects was an independent predictor of mortality at 12 months (HR: 2.90, 95% CI: 1.05, 8.06, p = 0.041). Conclusions: In a high-risk patient population with suspected stable CAD, only large reversible perfusion defects in SPECT MPI were independently associated with mortality at 1 year. Further trials are needed to validate our findings and refine the role of SPECT MPI findings in the diagnosis and prognosis of cardiovascular patients. MDPI 2023-05-22 /pmc/articles/PMC10223725/ /pubmed/37241041 http://dx.doi.org/10.3390/jpm13050871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Zotou, Paraskevi Bechlioulis, Aris Tsiouris, Spyridon Naka, Katerina K. Xourgia, Xanthi Pappas, Konstantinos Lakkas, Lampros Rammos, Aidonis Kalef-Ezra, John Michalis, Lampros K. Fotopoulos, Andreas The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title | The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title_full | The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title_fullStr | The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title_full_unstemmed | The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title_short | The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience |
title_sort | role of myocardial perfusion imaging in the prediction of major adverse cardiovascular events at 1 year follow-up: a single center’s experience |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223725/ https://www.ncbi.nlm.nih.gov/pubmed/37241041 http://dx.doi.org/10.3390/jpm13050871 |
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