GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis

G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage polarization. However, the role of GRK2 in the patho...

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Detalles Bibliográficos
Autores principales: Zhang, Jiawei, Zhang, Xianzheng, Lu, Mingdian, Chang, Yan, Wang, Qingtong, Tu, Jiajie, Wu, Huaxun, Wang, Chun, Hong, Zhongyang, Xiong, Maoming, Song, Lihua, Wei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223763/
https://www.ncbi.nlm.nih.gov/pubmed/37242446
http://dx.doi.org/10.3390/ph16050664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223763/
https://www.ncbi.nlm.nih.gov/pubmed/37242446
http://dx.doi.org/10.3390/ph16050664

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