Suicide gene therapy using allogeneic adipose tissue-derived mesenchymal stem cell gene delivery vehicles in recurrent glioblastoma multiforme: a first-in-human, dose-escalation, phase I clinical trial

BACKGROUND: Glioblastoma multiforme (GBM) is associated with remarkably poor prognosis, and its treatment is challenging. This investigation aimed to evaluate the safety of suicide gene therapy using allogeneic adipose tissue-derived mesenchymal stem cells (ADSCs) carrying herpes simplex virus-thymi...

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Detalles Bibliográficos
Autores principales: Oraee-Yazdani, Saeed, Tavanaei, Roozbeh, Rostami, Fatemeh, Hajarizadeh, Atieh, Mehrabadi, Marzieh, Akhlaghpasand, Mohammadhosein, Tamaddon, Mona, Khannejad, Samin, Yazdani, Kaveh Oraii, Zali, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223860/
https://www.ncbi.nlm.nih.gov/pubmed/37245011
http://dx.doi.org/10.1186/s12967-023-04213-4

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