Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; howev...

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Detalles Bibliográficos
Autores principales: Ma, TianRong, Xue, XiaoLei, Tian, Hui, Zhou, XinXiu, Wang, JunKe, Zhao, ZhiWen, Wang, MingFei, Song, JiYuan, Feng, RenXiang, Li, Leping, Jing, Changqing, Tian, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223893/
https://www.ncbi.nlm.nih.gov/pubmed/37237321
http://dx.doi.org/10.1186/s12967-023-04215-2
Descripción
Sumario:Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.

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