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Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats

Spina bifida, known more commonly as myelomeningocele, is a neural tube defect that results in herniation of the cerebellum through the foramen magnum into the central canal as part of the Chiari II malformation. Effects stemming from the herniated cerebellum and its metabolic profile have not been...

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Autores principales: Thielen, Evan, Oria, Marc, Watanabe-Chailland, Miki, Lampe, Kristin, Romick-Rosendale, Lindsey, Peiro, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223940/
https://www.ncbi.nlm.nih.gov/pubmed/37233711
http://dx.doi.org/10.3390/metabo13050670
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author Thielen, Evan
Oria, Marc
Watanabe-Chailland, Miki
Lampe, Kristin
Romick-Rosendale, Lindsey
Peiro, Jose L.
author_facet Thielen, Evan
Oria, Marc
Watanabe-Chailland, Miki
Lampe, Kristin
Romick-Rosendale, Lindsey
Peiro, Jose L.
author_sort Thielen, Evan
collection PubMed
description Spina bifida, known more commonly as myelomeningocele, is a neural tube defect that results in herniation of the cerebellum through the foramen magnum into the central canal as part of the Chiari II malformation. Effects stemming from the herniated cerebellum and its metabolic profile have not been extensively studied. The objective of this study is to examine the metabolic effects of this disease on the cerebellum in utero through the utilization of a retinoid acid-induced Spina bifida rat model. Analysis of this model at mid-late (day 15) and term (day 20) of gestation in comparison to both non-exposed and retinoic acid-exposed non-myelomeningocele controls, the observed metabolic changes suggest that mechanisms of oxidative stress and energy depletion are at play in this neuro tissue. These notable mechanisms are likely to result in further damage to neural tissue as the fetus grows and the compressed cerebellum develops and herniates more due to myelomeningocele.
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spelling pubmed-102239402023-05-28 Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats Thielen, Evan Oria, Marc Watanabe-Chailland, Miki Lampe, Kristin Romick-Rosendale, Lindsey Peiro, Jose L. Metabolites Article Spina bifida, known more commonly as myelomeningocele, is a neural tube defect that results in herniation of the cerebellum through the foramen magnum into the central canal as part of the Chiari II malformation. Effects stemming from the herniated cerebellum and its metabolic profile have not been extensively studied. The objective of this study is to examine the metabolic effects of this disease on the cerebellum in utero through the utilization of a retinoid acid-induced Spina bifida rat model. Analysis of this model at mid-late (day 15) and term (day 20) of gestation in comparison to both non-exposed and retinoic acid-exposed non-myelomeningocele controls, the observed metabolic changes suggest that mechanisms of oxidative stress and energy depletion are at play in this neuro tissue. These notable mechanisms are likely to result in further damage to neural tissue as the fetus grows and the compressed cerebellum develops and herniates more due to myelomeningocele. MDPI 2023-05-19 /pmc/articles/PMC10223940/ /pubmed/37233711 http://dx.doi.org/10.3390/metabo13050670 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thielen, Evan
Oria, Marc
Watanabe-Chailland, Miki
Lampe, Kristin
Romick-Rosendale, Lindsey
Peiro, Jose L.
Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title_full Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title_fullStr Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title_full_unstemmed Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title_short Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats
title_sort non-targeted metabolic profiling of cerebellum in spina bifida fetal rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223940/
https://www.ncbi.nlm.nih.gov/pubmed/37233711
http://dx.doi.org/10.3390/metabo13050670
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