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Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice

Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic granulomatous infection of renal parenchyma. XGP is often associated with long-term urinary tract obstruction due to stones and infection. We aimed to analyze the clinical, laboratory, and microbial culture profiles from bladder and kid...

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Autores principales: Gauhar, Vineet, Robles-Torres, José Iván, Wroclawski, Marcelo Langer, Trujillo-Santamaría, Hegel, Teoh, Jeremy Yuen Chun, Tanidir, Yiloren, Mahajan, Abhay, Gadzhiev, Nariman, Ragoori, Deepak, Kumar, Santosh, Ganpule, Arvind, Maheshwari, Pankaj Nandkishore, García-Chairez, Luis Roberto, Enrriquez-Ávila, Joana Valeria, Monzón-Falconi, Juan Francisco, Esqueda-Mendoza, Antonio, Flores-Tapia, Juan Pablo, Duarte-Santos, Hugo Octaviano, Farooq, Mudasir, Arjunrao Gite, Venkat, Mani Sinha, Mriganka, Somani, Bhaskar K., Castellani, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223950/
https://www.ncbi.nlm.nih.gov/pubmed/37242365
http://dx.doi.org/10.3390/pathogens12050695
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author Gauhar, Vineet
Robles-Torres, José Iván
Wroclawski, Marcelo Langer
Trujillo-Santamaría, Hegel
Teoh, Jeremy Yuen Chun
Tanidir, Yiloren
Mahajan, Abhay
Gadzhiev, Nariman
Ragoori, Deepak
Kumar, Santosh
Ganpule, Arvind
Maheshwari, Pankaj Nandkishore
García-Chairez, Luis Roberto
Enrriquez-Ávila, Joana Valeria
Monzón-Falconi, Juan Francisco
Esqueda-Mendoza, Antonio
Flores-Tapia, Juan Pablo
Duarte-Santos, Hugo Octaviano
Farooq, Mudasir
Arjunrao Gite, Venkat
Mani Sinha, Mriganka
Somani, Bhaskar K.
Castellani, Daniele
author_facet Gauhar, Vineet
Robles-Torres, José Iván
Wroclawski, Marcelo Langer
Trujillo-Santamaría, Hegel
Teoh, Jeremy Yuen Chun
Tanidir, Yiloren
Mahajan, Abhay
Gadzhiev, Nariman
Ragoori, Deepak
Kumar, Santosh
Ganpule, Arvind
Maheshwari, Pankaj Nandkishore
García-Chairez, Luis Roberto
Enrriquez-Ávila, Joana Valeria
Monzón-Falconi, Juan Francisco
Esqueda-Mendoza, Antonio
Flores-Tapia, Juan Pablo
Duarte-Santos, Hugo Octaviano
Farooq, Mudasir
Arjunrao Gite, Venkat
Mani Sinha, Mriganka
Somani, Bhaskar K.
Castellani, Daniele
author_sort Gauhar, Vineet
collection PubMed
description Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic granulomatous infection of renal parenchyma. XGP is often associated with long-term urinary tract obstruction due to stones and infection. We aimed to analyze the clinical, laboratory, and microbial culture profiles from bladder and kidney urine of patients who were diagnosed with XGP. Databases of patients with histopathological diagnosis of XGP from 10 centers across 5 countries were retrospectively reviewed between 2018 and 2022. Patients with incomplete medical records were excluded. A total of 365 patients were included. There were 228 (62.5%) women. The mean age was 45 ± 14.4 years. The most common comorbidity was chronic kidney disease (71%). Multiple stones were present in 34.5% of cases. Bladder urine culture results were positive in 53.2% of cases. Kidney urine culture was positive in 81.9% of patients. Sepsis and septic shock were present in 13.4% and 6.6% of patients, respectively. Three deaths were reported. Escherichia coli was the most common isolated pathogen in both urine (28.4%) and kidney cultures (42.4%), followed by Proteus mirabilis in bladder urine cultures (6.3%) and Klebsiella pneumoniae (7.6%) in kidney cultures. Extended-spectrum beta-lactamases producing bacteria were reported in 6% of the bladder urine cultures. On multivariable analysis, urosepsis, recurrent urinary tract infections, increased creatinine, and disease extension to perirenal and pararenal space were independent factors associated with positive bladder urine cultures. On multivariable analysis, only the presence of anemia was significantly more frequent in patients with positive kidney cultures. Our results can help urologists counsel XGP patients undergoing nephrectomy.
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spelling pubmed-102239502023-05-28 Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice Gauhar, Vineet Robles-Torres, José Iván Wroclawski, Marcelo Langer Trujillo-Santamaría, Hegel Teoh, Jeremy Yuen Chun Tanidir, Yiloren Mahajan, Abhay Gadzhiev, Nariman Ragoori, Deepak Kumar, Santosh Ganpule, Arvind Maheshwari, Pankaj Nandkishore García-Chairez, Luis Roberto Enrriquez-Ávila, Joana Valeria Monzón-Falconi, Juan Francisco Esqueda-Mendoza, Antonio Flores-Tapia, Juan Pablo Duarte-Santos, Hugo Octaviano Farooq, Mudasir Arjunrao Gite, Venkat Mani Sinha, Mriganka Somani, Bhaskar K. Castellani, Daniele Pathogens Article Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic granulomatous infection of renal parenchyma. XGP is often associated with long-term urinary tract obstruction due to stones and infection. We aimed to analyze the clinical, laboratory, and microbial culture profiles from bladder and kidney urine of patients who were diagnosed with XGP. Databases of patients with histopathological diagnosis of XGP from 10 centers across 5 countries were retrospectively reviewed between 2018 and 2022. Patients with incomplete medical records were excluded. A total of 365 patients were included. There were 228 (62.5%) women. The mean age was 45 ± 14.4 years. The most common comorbidity was chronic kidney disease (71%). Multiple stones were present in 34.5% of cases. Bladder urine culture results were positive in 53.2% of cases. Kidney urine culture was positive in 81.9% of patients. Sepsis and septic shock were present in 13.4% and 6.6% of patients, respectively. Three deaths were reported. Escherichia coli was the most common isolated pathogen in both urine (28.4%) and kidney cultures (42.4%), followed by Proteus mirabilis in bladder urine cultures (6.3%) and Klebsiella pneumoniae (7.6%) in kidney cultures. Extended-spectrum beta-lactamases producing bacteria were reported in 6% of the bladder urine cultures. On multivariable analysis, urosepsis, recurrent urinary tract infections, increased creatinine, and disease extension to perirenal and pararenal space were independent factors associated with positive bladder urine cultures. On multivariable analysis, only the presence of anemia was significantly more frequent in patients with positive kidney cultures. Our results can help urologists counsel XGP patients undergoing nephrectomy. MDPI 2023-05-10 /pmc/articles/PMC10223950/ /pubmed/37242365 http://dx.doi.org/10.3390/pathogens12050695 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gauhar, Vineet
Robles-Torres, José Iván
Wroclawski, Marcelo Langer
Trujillo-Santamaría, Hegel
Teoh, Jeremy Yuen Chun
Tanidir, Yiloren
Mahajan, Abhay
Gadzhiev, Nariman
Ragoori, Deepak
Kumar, Santosh
Ganpule, Arvind
Maheshwari, Pankaj Nandkishore
García-Chairez, Luis Roberto
Enrriquez-Ávila, Joana Valeria
Monzón-Falconi, Juan Francisco
Esqueda-Mendoza, Antonio
Flores-Tapia, Juan Pablo
Duarte-Santos, Hugo Octaviano
Farooq, Mudasir
Arjunrao Gite, Venkat
Mani Sinha, Mriganka
Somani, Bhaskar K.
Castellani, Daniele
Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title_full Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title_fullStr Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title_full_unstemmed Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title_short Clinical Presentation, Microbiological Characteristics, and Their Implications for Perioperative Outcomes in Xanthogranulomatous Pyelonephritis: Perspectives from a Real-World Multicenter Practice
title_sort clinical presentation, microbiological characteristics, and their implications for perioperative outcomes in xanthogranulomatous pyelonephritis: perspectives from a real-world multicenter practice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223950/
https://www.ncbi.nlm.nih.gov/pubmed/37242365
http://dx.doi.org/10.3390/pathogens12050695
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