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Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy

Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction...

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Autores principales: Lee-Sarwar, Kathleen A., Fischer-Rasmussen, Kasper, Bønnelykke, Klaus, Bisgaard, Hans, Chawes, Bo, Kelly, Rachel S., Lasky-Su, Jessica, Zeiger, Robert S., O’Connor, George T., Bacharier, Leonard B., Carey, Vincent J., Laranjo, Nancy, Litonjua, Augusto A., Weiss, Scott T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223962/
https://www.ncbi.nlm.nih.gov/pubmed/37242299
http://dx.doi.org/10.3390/nu15102416
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author Lee-Sarwar, Kathleen A.
Fischer-Rasmussen, Kasper
Bønnelykke, Klaus
Bisgaard, Hans
Chawes, Bo
Kelly, Rachel S.
Lasky-Su, Jessica
Zeiger, Robert S.
O’Connor, George T.
Bacharier, Leonard B.
Carey, Vincent J.
Laranjo, Nancy
Litonjua, Augusto A.
Weiss, Scott T.
author_facet Lee-Sarwar, Kathleen A.
Fischer-Rasmussen, Kasper
Bønnelykke, Klaus
Bisgaard, Hans
Chawes, Bo
Kelly, Rachel S.
Lasky-Su, Jessica
Zeiger, Robert S.
O’Connor, George T.
Bacharier, Leonard B.
Carey, Vincent J.
Laranjo, Nancy
Litonjua, Augusto A.
Weiss, Scott T.
author_sort Lee-Sarwar, Kathleen A.
collection PubMed
description Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region.
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spelling pubmed-102239622023-05-28 Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy Lee-Sarwar, Kathleen A. Fischer-Rasmussen, Kasper Bønnelykke, Klaus Bisgaard, Hans Chawes, Bo Kelly, Rachel S. Lasky-Su, Jessica Zeiger, Robert S. O’Connor, George T. Bacharier, Leonard B. Carey, Vincent J. Laranjo, Nancy Litonjua, Augusto A. Weiss, Scott T. Nutrients Article Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region. MDPI 2023-05-22 /pmc/articles/PMC10223962/ /pubmed/37242299 http://dx.doi.org/10.3390/nu15102416 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee-Sarwar, Kathleen A.
Fischer-Rasmussen, Kasper
Bønnelykke, Klaus
Bisgaard, Hans
Chawes, Bo
Kelly, Rachel S.
Lasky-Su, Jessica
Zeiger, Robert S.
O’Connor, George T.
Bacharier, Leonard B.
Carey, Vincent J.
Laranjo, Nancy
Litonjua, Augusto A.
Weiss, Scott T.
Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title_full Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title_fullStr Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title_full_unstemmed Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title_short Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
title_sort omega-3 fatty acids interact with dpp10 region genotype in association with childhood atopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223962/
https://www.ncbi.nlm.nih.gov/pubmed/37242299
http://dx.doi.org/10.3390/nu15102416
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