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Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223962/ https://www.ncbi.nlm.nih.gov/pubmed/37242299 http://dx.doi.org/10.3390/nu15102416 |
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author | Lee-Sarwar, Kathleen A. Fischer-Rasmussen, Kasper Bønnelykke, Klaus Bisgaard, Hans Chawes, Bo Kelly, Rachel S. Lasky-Su, Jessica Zeiger, Robert S. O’Connor, George T. Bacharier, Leonard B. Carey, Vincent J. Laranjo, Nancy Litonjua, Augusto A. Weiss, Scott T. |
author_facet | Lee-Sarwar, Kathleen A. Fischer-Rasmussen, Kasper Bønnelykke, Klaus Bisgaard, Hans Chawes, Bo Kelly, Rachel S. Lasky-Su, Jessica Zeiger, Robert S. O’Connor, George T. Bacharier, Leonard B. Carey, Vincent J. Laranjo, Nancy Litonjua, Augusto A. Weiss, Scott T. |
author_sort | Lee-Sarwar, Kathleen A. |
collection | PubMed |
description | Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region. |
format | Online Article Text |
id | pubmed-10223962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102239622023-05-28 Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy Lee-Sarwar, Kathleen A. Fischer-Rasmussen, Kasper Bønnelykke, Klaus Bisgaard, Hans Chawes, Bo Kelly, Rachel S. Lasky-Su, Jessica Zeiger, Robert S. O’Connor, George T. Bacharier, Leonard B. Carey, Vincent J. Laranjo, Nancy Litonjua, Augusto A. Weiss, Scott T. Nutrients Article Associations of omega-3 fatty acids (n-3) with allergic diseases are inconsistent, perhaps in part due to genetic variation. We sought to identify and validate genetic variants that modify associations of n-3 with childhood asthma or atopy in participants in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC). Dietary n-3 was derived from food frequency questionnaires and plasma n-3 was measured via untargeted mass spectrometry in early childhood and children aged 6 years old. Interactions of genotype with n-3 in association with asthma or atopy at age 6 years were sought for six candidate genes/gene regions and genome-wide. Two SNPs in the region of DPP10 (rs958457 and rs1516311) interacted with plasma n-3 at age 3 years in VDAART (p = 0.007 and 0.003, respectively) and with plasma n-3 at age 18 months in COPSAC (p = 0.01 and 0.02, respectively) in associationwith atopy. Another DPP10 region SNP, rs1367180, interacted with dietary n-3 at age 6 years in VDAART (p = 0.009) and with plasma n-3 at age 6 years in COPSAC (p = 0.004) in association with atopy. No replicated interactions were identified for asthma. The effect of n-3 on reducing childhood allergic disease may differ by individual factors, including genetic variation in the DPP10 region. MDPI 2023-05-22 /pmc/articles/PMC10223962/ /pubmed/37242299 http://dx.doi.org/10.3390/nu15102416 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee-Sarwar, Kathleen A. Fischer-Rasmussen, Kasper Bønnelykke, Klaus Bisgaard, Hans Chawes, Bo Kelly, Rachel S. Lasky-Su, Jessica Zeiger, Robert S. O’Connor, George T. Bacharier, Leonard B. Carey, Vincent J. Laranjo, Nancy Litonjua, Augusto A. Weiss, Scott T. Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title | Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title_full | Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title_fullStr | Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title_full_unstemmed | Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title_short | Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy |
title_sort | omega-3 fatty acids interact with dpp10 region genotype in association with childhood atopy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223962/ https://www.ncbi.nlm.nih.gov/pubmed/37242299 http://dx.doi.org/10.3390/nu15102416 |
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