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Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion

Malignant pleural effusion is associated with a poor prognosis and, while risk stratification models exist, prior studies have not evaluated pleural fluid resolution and its association with survival. We performed a retrospective review of patients diagnosed with malignant pleural effusion between 2...

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Autores principales: MacRosty, Christina R., Wright, Amber, Ceppe, Agathe, Ghosh, Sohini, Burks, A. Cole, Akulian, Jason A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223971/
https://www.ncbi.nlm.nih.gov/pubmed/37240808
http://dx.doi.org/10.3390/life13051163
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author MacRosty, Christina R.
Wright, Amber
Ceppe, Agathe
Ghosh, Sohini
Burks, A. Cole
Akulian, Jason A.
author_facet MacRosty, Christina R.
Wright, Amber
Ceppe, Agathe
Ghosh, Sohini
Burks, A. Cole
Akulian, Jason A.
author_sort MacRosty, Christina R.
collection PubMed
description Malignant pleural effusion is associated with a poor prognosis and, while risk stratification models exist, prior studies have not evaluated pleural fluid resolution and its association with survival. We performed a retrospective review of patients diagnosed with malignant pleural effusion between 2013 and 2017, evaluating patient demographics, pleural fluid and serum composition, and procedural and treatment data using Cox regression analysis to evaluate associations with survival. In total, 123 patients were included in the study, with median survival from diagnosis being 4.8 months. Resolution of malignant pleural fluid was associated with a significant survival benefit, even when accounting for factors such as placement of an indwelling pleural catheter, anti-cancer therapy, pleural fluid cytology, cancer pheno/genotypes, and pleural fluid characteristics. Elevated fluid protein, placement of an indwelling pleural catheter, and treatment with targeted or hormone therapies were associated with pleural fluid resolution. We conclude that the resolution of pleural fluid accumulation in patients with malignant pleural effusion is associated with a survival benefit possibility representing a surrogate marker for treatment of the underlying metastatic cancer. These findings support the need to better understand the mechanism of fluid resolution in patients with malignant pleural effusion as well as the tumor–immune interplay occurring with the malignant pleural space.
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spelling pubmed-102239712023-05-28 Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion MacRosty, Christina R. Wright, Amber Ceppe, Agathe Ghosh, Sohini Burks, A. Cole Akulian, Jason A. Life (Basel) Article Malignant pleural effusion is associated with a poor prognosis and, while risk stratification models exist, prior studies have not evaluated pleural fluid resolution and its association with survival. We performed a retrospective review of patients diagnosed with malignant pleural effusion between 2013 and 2017, evaluating patient demographics, pleural fluid and serum composition, and procedural and treatment data using Cox regression analysis to evaluate associations with survival. In total, 123 patients were included in the study, with median survival from diagnosis being 4.8 months. Resolution of malignant pleural fluid was associated with a significant survival benefit, even when accounting for factors such as placement of an indwelling pleural catheter, anti-cancer therapy, pleural fluid cytology, cancer pheno/genotypes, and pleural fluid characteristics. Elevated fluid protein, placement of an indwelling pleural catheter, and treatment with targeted or hormone therapies were associated with pleural fluid resolution. We conclude that the resolution of pleural fluid accumulation in patients with malignant pleural effusion is associated with a survival benefit possibility representing a surrogate marker for treatment of the underlying metastatic cancer. These findings support the need to better understand the mechanism of fluid resolution in patients with malignant pleural effusion as well as the tumor–immune interplay occurring with the malignant pleural space. MDPI 2023-05-11 /pmc/articles/PMC10223971/ /pubmed/37240808 http://dx.doi.org/10.3390/life13051163 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
MacRosty, Christina R.
Wright, Amber
Ceppe, Agathe
Ghosh, Sohini
Burks, A. Cole
Akulian, Jason A.
Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title_full Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title_fullStr Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title_full_unstemmed Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title_short Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion
title_sort pleural fluid resolution is associated with improved survival in patients with malignant pleural effusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223971/
https://www.ncbi.nlm.nih.gov/pubmed/37240808
http://dx.doi.org/10.3390/life13051163
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