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Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224024/ https://www.ncbi.nlm.nih.gov/pubmed/37242674 http://dx.doi.org/10.3390/pharmaceutics15051432 |
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author | Khaliq, Nisar Ul Lee, Juyeon Kim, Joohyeon Kim, Yejin Yu, Sohyeon Kim, Jisu Kim, Sangwoo Sung, Daekyung Kim, Hyungjun |
author_facet | Khaliq, Nisar Ul Lee, Juyeon Kim, Joohyeon Kim, Yejin Yu, Sohyeon Kim, Jisu Kim, Sangwoo Sung, Daekyung Kim, Hyungjun |
author_sort | Khaliq, Nisar Ul |
collection | PubMed |
description | Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier, including high loading capacity, controlled drug release, and easy surface functionalization. MSNs are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies demonstrating the use of MSNs for the delivery of therapeutic nucleic acids to cancer cells have been reviewed, along with their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are discussed. |
format | Online Article Text |
id | pubmed-10224024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102240242023-05-28 Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy Khaliq, Nisar Ul Lee, Juyeon Kim, Joohyeon Kim, Yejin Yu, Sohyeon Kim, Jisu Kim, Sangwoo Sung, Daekyung Kim, Hyungjun Pharmaceutics Review Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier, including high loading capacity, controlled drug release, and easy surface functionalization. MSNs are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies demonstrating the use of MSNs for the delivery of therapeutic nucleic acids to cancer cells have been reviewed, along with their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are discussed. MDPI 2023-05-08 /pmc/articles/PMC10224024/ /pubmed/37242674 http://dx.doi.org/10.3390/pharmaceutics15051432 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khaliq, Nisar Ul Lee, Juyeon Kim, Joohyeon Kim, Yejin Yu, Sohyeon Kim, Jisu Kim, Sangwoo Sung, Daekyung Kim, Hyungjun Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title | Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title_full | Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title_fullStr | Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title_full_unstemmed | Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title_short | Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy |
title_sort | mesoporous silica nanoparticles as a gene delivery platform for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224024/ https://www.ncbi.nlm.nih.gov/pubmed/37242674 http://dx.doi.org/10.3390/pharmaceutics15051432 |
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