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Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy

Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier,...

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Autores principales: Khaliq, Nisar Ul, Lee, Juyeon, Kim, Joohyeon, Kim, Yejin, Yu, Sohyeon, Kim, Jisu, Kim, Sangwoo, Sung, Daekyung, Kim, Hyungjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224024/
https://www.ncbi.nlm.nih.gov/pubmed/37242674
http://dx.doi.org/10.3390/pharmaceutics15051432
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author Khaliq, Nisar Ul
Lee, Juyeon
Kim, Joohyeon
Kim, Yejin
Yu, Sohyeon
Kim, Jisu
Kim, Sangwoo
Sung, Daekyung
Kim, Hyungjun
author_facet Khaliq, Nisar Ul
Lee, Juyeon
Kim, Joohyeon
Kim, Yejin
Yu, Sohyeon
Kim, Jisu
Kim, Sangwoo
Sung, Daekyung
Kim, Hyungjun
author_sort Khaliq, Nisar Ul
collection PubMed
description Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier, including high loading capacity, controlled drug release, and easy surface functionalization. MSNs are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies demonstrating the use of MSNs for the delivery of therapeutic nucleic acids to cancer cells have been reviewed, along with their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are discussed.
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spelling pubmed-102240242023-05-28 Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy Khaliq, Nisar Ul Lee, Juyeon Kim, Joohyeon Kim, Yejin Yu, Sohyeon Kim, Jisu Kim, Sangwoo Sung, Daekyung Kim, Hyungjun Pharmaceutics Review Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier, including high loading capacity, controlled drug release, and easy surface functionalization. MSNs are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies demonstrating the use of MSNs for the delivery of therapeutic nucleic acids to cancer cells have been reviewed, along with their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are discussed. MDPI 2023-05-08 /pmc/articles/PMC10224024/ /pubmed/37242674 http://dx.doi.org/10.3390/pharmaceutics15051432 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khaliq, Nisar Ul
Lee, Juyeon
Kim, Joohyeon
Kim, Yejin
Yu, Sohyeon
Kim, Jisu
Kim, Sangwoo
Sung, Daekyung
Kim, Hyungjun
Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title_full Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title_fullStr Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title_full_unstemmed Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title_short Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
title_sort mesoporous silica nanoparticles as a gene delivery platform for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224024/
https://www.ncbi.nlm.nih.gov/pubmed/37242674
http://dx.doi.org/10.3390/pharmaceutics15051432
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