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Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer
Cold atmospheric plasma (CAP) may have applications in treating various types of malignant tumors. This study assessed the anticancer effects of CAP using melanoma and colon cancer cell lines. CAP treatment significantly reduced the in vitro viability of melanoma and colon cancer cell lines and had...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224096/ https://www.ncbi.nlm.nih.gov/pubmed/37241912 http://dx.doi.org/10.3390/molecules28104171 |
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author | Jung, Joon-Min Yoon, Hae-Kyeong Kim, Su-Yeon Yun, Mi-Ra Kim, Gyeong-Hoon Lee, Woo-Jin Lee, Mi-Woo Chang, Sung-Eun Won, Chong-Hyun |
author_facet | Jung, Joon-Min Yoon, Hae-Kyeong Kim, Su-Yeon Yun, Mi-Ra Kim, Gyeong-Hoon Lee, Woo-Jin Lee, Mi-Woo Chang, Sung-Eun Won, Chong-Hyun |
author_sort | Jung, Joon-Min |
collection | PubMed |
description | Cold atmospheric plasma (CAP) may have applications in treating various types of malignant tumors. This study assessed the anticancer effects of CAP using melanoma and colon cancer cell lines. CAP treatment significantly reduced the in vitro viability of melanoma and colon cancer cell lines and had a negligible effect on the viability of normal human melanocytes. Additionally, CAP and epidermal growth factor receptor (EGFR) inhibitor had an additive anticancer effect in a CAP-resistant melanoma cell line. Reactive oxygen and nitrogen species known to be generated by CAP enhanced the anticancer effects of CAP and EGFR inhibitors. The in vivo anticancer activities of CAP were evaluated by testing its effects against syngeneic tumors induced in mice by melanoma and colon cancer cells. CAP treatment reduced tumor volume and weight in both cancer models, with the extent of tumor reduction dependent on the duration and number of CAP treatments. Histologic examination also revealed the tumoricidal effects of CAP in both tumor models. In conclusion, CAP inhibits the growth of mouse melanoma and colon cancer cell lines in vitro and shows tumoricidal effects against mouse models of melanoma and colon cancer in vivo. |
format | Online Article Text |
id | pubmed-10224096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102240962023-05-28 Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer Jung, Joon-Min Yoon, Hae-Kyeong Kim, Su-Yeon Yun, Mi-Ra Kim, Gyeong-Hoon Lee, Woo-Jin Lee, Mi-Woo Chang, Sung-Eun Won, Chong-Hyun Molecules Article Cold atmospheric plasma (CAP) may have applications in treating various types of malignant tumors. This study assessed the anticancer effects of CAP using melanoma and colon cancer cell lines. CAP treatment significantly reduced the in vitro viability of melanoma and colon cancer cell lines and had a negligible effect on the viability of normal human melanocytes. Additionally, CAP and epidermal growth factor receptor (EGFR) inhibitor had an additive anticancer effect in a CAP-resistant melanoma cell line. Reactive oxygen and nitrogen species known to be generated by CAP enhanced the anticancer effects of CAP and EGFR inhibitors. The in vivo anticancer activities of CAP were evaluated by testing its effects against syngeneic tumors induced in mice by melanoma and colon cancer cells. CAP treatment reduced tumor volume and weight in both cancer models, with the extent of tumor reduction dependent on the duration and number of CAP treatments. Histologic examination also revealed the tumoricidal effects of CAP in both tumor models. In conclusion, CAP inhibits the growth of mouse melanoma and colon cancer cell lines in vitro and shows tumoricidal effects against mouse models of melanoma and colon cancer in vivo. MDPI 2023-05-18 /pmc/articles/PMC10224096/ /pubmed/37241912 http://dx.doi.org/10.3390/molecules28104171 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jung, Joon-Min Yoon, Hae-Kyeong Kim, Su-Yeon Yun, Mi-Ra Kim, Gyeong-Hoon Lee, Woo-Jin Lee, Mi-Woo Chang, Sung-Eun Won, Chong-Hyun Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title | Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title_full | Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title_fullStr | Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title_full_unstemmed | Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title_short | Anticancer Effect of Cold Atmospheric Plasma in Syngeneic Mouse Models of Melanoma and Colon Cancer |
title_sort | anticancer effect of cold atmospheric plasma in syngeneic mouse models of melanoma and colon cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224096/ https://www.ncbi.nlm.nih.gov/pubmed/37241912 http://dx.doi.org/10.3390/molecules28104171 |
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