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Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease

The neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy...

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Autores principales: Vitório, Rodrigo, Lirani-Silva, Ellen, Orcioli-Silva, Diego, Beretta, Victor Spiandor, Oliveira, Anderson Souza, Gobbi, Lilian Teresa Bucken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224292/
https://www.ncbi.nlm.nih.gov/pubmed/37430780
http://dx.doi.org/10.3390/s23104866
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author Vitório, Rodrigo
Lirani-Silva, Ellen
Orcioli-Silva, Diego
Beretta, Victor Spiandor
Oliveira, Anderson Souza
Gobbi, Lilian Teresa Bucken
author_facet Vitório, Rodrigo
Lirani-Silva, Ellen
Orcioli-Silva, Diego
Beretta, Victor Spiandor
Oliveira, Anderson Souza
Gobbi, Lilian Teresa Bucken
author_sort Vitório, Rodrigo
collection PubMed
description The neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy individuals. Fifteen people with PD and fourteen older adults walked overground in two conditions: usual walking and obstacle crossing. Scalp electroencephalography (EEG) was recorded using a mobile 64-channel EEG system. Independent components were clustered using a k-means clustering algorithm. Outcome measures included absolute power in several frequency bands and alpha/beta ratio. During the usual walk, people with PD presented a greater alpha/beta ratio in the left sensorimotor cortex than healthy individuals. While approaching obstacles, both groups reduced alpha and beta power in the premotor and right sensorimotor cortices (balance demand) and increased gamma power in the primary visual cortex (visual demand). Only people with PD reduced alpha power and alpha/beta ratio in the left sensorimotor cortex when approaching obstacles. These findings suggest that PD affects the cortical control of usual walking, leading to a greater proportion of low-frequency (alpha) neuronal firing in the sensorimotor cortex. Moreover, the planning for obstacle avoidance changes the electrocortical dynamics associated with increased balance and visual demands. People with PD rely on increased sensorimotor integration to modulate locomotion.
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spelling pubmed-102242922023-05-28 Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease Vitório, Rodrigo Lirani-Silva, Ellen Orcioli-Silva, Diego Beretta, Victor Spiandor Oliveira, Anderson Souza Gobbi, Lilian Teresa Bucken Sensors (Basel) Article The neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy individuals. Fifteen people with PD and fourteen older adults walked overground in two conditions: usual walking and obstacle crossing. Scalp electroencephalography (EEG) was recorded using a mobile 64-channel EEG system. Independent components were clustered using a k-means clustering algorithm. Outcome measures included absolute power in several frequency bands and alpha/beta ratio. During the usual walk, people with PD presented a greater alpha/beta ratio in the left sensorimotor cortex than healthy individuals. While approaching obstacles, both groups reduced alpha and beta power in the premotor and right sensorimotor cortices (balance demand) and increased gamma power in the primary visual cortex (visual demand). Only people with PD reduced alpha power and alpha/beta ratio in the left sensorimotor cortex when approaching obstacles. These findings suggest that PD affects the cortical control of usual walking, leading to a greater proportion of low-frequency (alpha) neuronal firing in the sensorimotor cortex. Moreover, the planning for obstacle avoidance changes the electrocortical dynamics associated with increased balance and visual demands. People with PD rely on increased sensorimotor integration to modulate locomotion. MDPI 2023-05-18 /pmc/articles/PMC10224292/ /pubmed/37430780 http://dx.doi.org/10.3390/s23104866 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vitório, Rodrigo
Lirani-Silva, Ellen
Orcioli-Silva, Diego
Beretta, Victor Spiandor
Oliveira, Anderson Souza
Gobbi, Lilian Teresa Bucken
Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title_full Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title_fullStr Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title_full_unstemmed Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title_short Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
title_sort electrocortical dynamics of usual walking and the planning to step over obstacles in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224292/
https://www.ncbi.nlm.nih.gov/pubmed/37430780
http://dx.doi.org/10.3390/s23104866
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