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Characterization of Pharmaceutical Tablets by X-ray Tomography
Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug produc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224568/ https://www.ncbi.nlm.nih.gov/pubmed/37242516 http://dx.doi.org/10.3390/ph16050733 |
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author | Vijayakumar, Jaianth Goudarzi, Niloofar Moazami Eeckhaut, Guy Schrijnemakers, Koen Cnudde, Veerle Boone, Matthieu N. |
author_facet | Vijayakumar, Jaianth Goudarzi, Niloofar Moazami Eeckhaut, Guy Schrijnemakers, Koen Cnudde, Veerle Boone, Matthieu N. |
author_sort | Vijayakumar, Jaianth |
collection | PubMed |
description | Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry. |
format | Online Article Text |
id | pubmed-10224568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102245682023-05-28 Characterization of Pharmaceutical Tablets by X-ray Tomography Vijayakumar, Jaianth Goudarzi, Niloofar Moazami Eeckhaut, Guy Schrijnemakers, Koen Cnudde, Veerle Boone, Matthieu N. Pharmaceuticals (Basel) Review Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry. MDPI 2023-05-11 /pmc/articles/PMC10224568/ /pubmed/37242516 http://dx.doi.org/10.3390/ph16050733 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vijayakumar, Jaianth Goudarzi, Niloofar Moazami Eeckhaut, Guy Schrijnemakers, Koen Cnudde, Veerle Boone, Matthieu N. Characterization of Pharmaceutical Tablets by X-ray Tomography |
title | Characterization of Pharmaceutical Tablets by X-ray Tomography |
title_full | Characterization of Pharmaceutical Tablets by X-ray Tomography |
title_fullStr | Characterization of Pharmaceutical Tablets by X-ray Tomography |
title_full_unstemmed | Characterization of Pharmaceutical Tablets by X-ray Tomography |
title_short | Characterization of Pharmaceutical Tablets by X-ray Tomography |
title_sort | characterization of pharmaceutical tablets by x-ray tomography |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224568/ https://www.ncbi.nlm.nih.gov/pubmed/37242516 http://dx.doi.org/10.3390/ph16050733 |
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