Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)

BACKGROUND: Shiga toxin-producing E. coli (STEC) infections affect children and adults worldwide, and treatment remain solely supportive. Up to 15–20% of children infected by high-risk STEC (i.e., E. coli that produce Shiga toxin 2) develop hemolytic anemia, thrombocytopenia, and kidney failure (i.e...

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Detalles Bibliográficos
Autores principales: Freedman, Stephen B., Schnadower, David, Estes, Myka, Casper, T. Charles, Goldstein, Stuart L., Grisaru, Silviu, Pavia, Andrew T., Wilfond, Benjamin S., Metheney, Melissa, Kimball, Kadyn, Tarr, Phillip I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224603/
https://www.ncbi.nlm.nih.gov/pubmed/37245030
http://dx.doi.org/10.1186/s13063-023-07379-w

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