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CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

BACKGROUND: B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4 domain is required for anti-apoptotic activity. Bcl-2 can be...

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Detalles Bibliográficos
Autores principales:	Lin, Yihua, Zhao, Yiling, Chen, Minggui, Li, Zishuo, Liu, Qiao, Chen, Jian, Ding, Yi, Ding, Chunyong, Ding, Ye, Qi, Cuiling, Zheng, Lingyun, Li, Jiangchao, Zhang, Rongxin, Zhou, Jia, Wang, Lijing, Zhang, Qian-Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224611/ https://www.ncbi.nlm.nih.gov/pubmed/37237269 http://dx.doi.org/10.1186/s12885-023-10974-4

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