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Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives

Overactive bladder (OAB) is a common and distressing condition which is known to have a significant effect on Health-Related Quality of Life (HRQoL). Whilst all patients complaining of overactive bladder symptoms will, in theory, initially benefit from conservative measures, many will require pharma...

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Autores principales: Robinson, Dudley, O’Kane, Miriam, Cardozo, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224686/
https://www.ncbi.nlm.nih.gov/pubmed/37251090
http://dx.doi.org/10.2147/IJWH.S369588
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author Robinson, Dudley
O’Kane, Miriam
Cardozo, Linda
author_facet Robinson, Dudley
O’Kane, Miriam
Cardozo, Linda
author_sort Robinson, Dudley
collection PubMed
description Overactive bladder (OAB) is a common and distressing condition which is known to have a significant effect on Health-Related Quality of Life (HRQoL). Whilst all patients complaining of overactive bladder symptoms will, in theory, initially benefit from conservative measures, many will require pharmacological therapy. Antimuscarinics currently remain the most commonly used drugs to treat OAB although compliance and persistence can be poor due to concerns regarding adverse events and lack of efficacy. This review will explore the common management strategies for OAB with a particular focus on patient adherence to therapy including compliance and persistence. The role of antimuscarinics and the B3-agonist, mirabegron, will be considered along with barriers to their efficacy and adoption. For those patients in whom conservative and pharmacological treatment proves ineffective or is unsuitable, the management of refractory OAB will also be considered. In addition, the role of current and future developments will be examined.
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spelling pubmed-102246862023-05-28 Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives Robinson, Dudley O’Kane, Miriam Cardozo, Linda Int J Womens Health Review Overactive bladder (OAB) is a common and distressing condition which is known to have a significant effect on Health-Related Quality of Life (HRQoL). Whilst all patients complaining of overactive bladder symptoms will, in theory, initially benefit from conservative measures, many will require pharmacological therapy. Antimuscarinics currently remain the most commonly used drugs to treat OAB although compliance and persistence can be poor due to concerns regarding adverse events and lack of efficacy. This review will explore the common management strategies for OAB with a particular focus on patient adherence to therapy including compliance and persistence. The role of antimuscarinics and the B3-agonist, mirabegron, will be considered along with barriers to their efficacy and adoption. For those patients in whom conservative and pharmacological treatment proves ineffective or is unsuitable, the management of refractory OAB will also be considered. In addition, the role of current and future developments will be examined. Dove 2023-05-23 /pmc/articles/PMC10224686/ /pubmed/37251090 http://dx.doi.org/10.2147/IJWH.S369588 Text en © 2023 Robinson et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Robinson, Dudley
O’Kane, Miriam
Cardozo, Linda
Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title_full Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title_fullStr Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title_full_unstemmed Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title_short Adherence to Overactive Bladder Syndrome Treatments Recent Developments and Future Perspectives
title_sort adherence to overactive bladder syndrome treatments recent developments and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224686/
https://www.ncbi.nlm.nih.gov/pubmed/37251090
http://dx.doi.org/10.2147/IJWH.S369588
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