Cargando…

Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study)

OBJECTIVE: Randomized trials testing the effect of antibiotics for chronic low back pain (LBP) with vertebral bone marrow changes on MRI (Modic changes) report inconsistent results. A proposed explanation is subgroups with low grade discitis where antibiotics are effective, but there is currently no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bråten, Lars Christian Haugli, Gjefsen, Elisabeth, Gervin, Kristina, Pripp, Are Hugo, Skouen, Jan Sture, Schistad, Elina, Pedersen, Linda Margareth, Wigemyr, Monica, Selmer, Kaja Kristine, Aass, Hans Christian Dalsbotten, Goll, Guro, Brox, Jens Ivar, Espeland, Ansgar, Grøvle, Lars, Zwart, John-Anker, Storheim, Kjersti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Clinical Trial Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224727/ https://www.ncbi.nlm.nih.gov/pubmed/37252109 http://dx.doi.org/10.2147/JPR.S406079

Ejemplares similares

Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes
por: Gjefsen, Elisabeth, et al.
Publicado: (2021)

Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
por: Vigeland, Maria Dehli, et al.
Publicado: (2023)

Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study
por: Bråten, Lars Christian Haugli, et al.
Publicado: (2020)

Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
por: Vigeland, Maria Dehli, et al.
Publicado: (2022)

The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
por: Gjefsen, Elisabeth, et al.
Publicado: (2020)

Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study)
por: Bråten, Lars Christian Haugli, et al.
Publicado: (2020)

Longitudinal Relationship Between Reduced Modic Change Edema and Disability and Pain in Patients With Chronic Low Back Pain
por: Espeland, Ansgar, et al.
Publicado: (2023)

Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain: Subgroup Analyses of a Randomised Trial (the AIM Study)
por: Kristoffersen, Per M., et al.
Publicado: (2023)

Cost–utility analysis of antibiotic treatment in patients with chronic low back pain and Modic changes: results from a randomised, placebo-controlled trial in Norway (the AIM study)
por: Grotle, Margreth, et al.
Publicado: (2020)

Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes—subgroup analysis of a randomized trial
por: Kristoffersen, Per Martin, et al.
Publicado: (2020)

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
por: Bråten, Lars Christian Haugli, et al.
Publicado: (2019)

Apparent diffusion coefficient values in Modic changes – interobserver reproducibility and relation to Modic type
por: Dagestad, Magnhild H., et al.
Publicado: (2022)

Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial
por: Storheim, Kjersti, et al.
Publicado: (2017)

Short tau inversion recovery MRI of Modic changes: a reliability study
por: Kristoffersen, Per Martin, et al.
Publicado: (2020)

Modic changes—Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis
por: Herlin, Christofer, et al.
Publicado: (2018)

Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome
por: Dhariwal, Achal, et al.
Publicado: (2022)

No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial
por: Wilkens, Philip, et al.
Publicado: (2012)

Lumbar spine surgery across 15 years: trends, complications and reoperations in a longitudinal observational study from Norway
por: Grotle, Margreth, et al.
Publicado: (2019)

Impact of educational level and employment status on short-term and long-term pain relief from supervised exercise therapy and education: an observational study of 22 588 patients with knee and hip osteoarthritis
por: Johnsen, Marianne Bakke, et al.
Publicado: (2021)

Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease
por: Johnsen, Lars G, et al.
Publicado: (2013)

Surgery with disc prosthesis versus rehabilitation in patients with low back pain and degenerative disc: two year follow-up of randomised study
por: Hellum, Christian, et al.
Publicado: (2011)

Fat in the lumbar multifidus muscles - predictive value and change following disc prosthesis surgery and multidisciplinary rehabilitation in patients with chronic low back pain and degenerative disc: 2-year follow-up of a randomized trial
por: Storheim, Kjersti, et al.
Publicado: (2017)

Subjective health complaints in patients with lumbar radicular pain and disc herniation are associated with a sex - OPRM1 A118G polymorphism interaction: a prospective 1-year observational study
por: Hasvik, Eivind, et al.
Publicado: (2014)

Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume
por: Ormstad, Heidi, et al.
Publicado: (2011)

Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients
por: Ormstad, Heidi, et al.
Publicado: (2011)

Erratum to: Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients
por: Ormstad, Heidi, et al.
Publicado: (2011)

Erratum to: Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume
por: Ormstad, Heidi, et al.
Publicado: (2011)

A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study
por: Banitalebi, Hasan, et al.
Publicado: (2022)

Up-regulation of circulating microRNA-17 is associated with lumbar radicular pain following disc herniation
por: Hasvik, Eivind, et al.
Publicado: (2019)

Comparative Effectiveness of Microdecompression Alone vs Decompression Plus Instrumented Fusion in Lumbar Degenerative Spondylolisthesis
por: Austevoll, Ivar Magne, et al.
Publicado: (2020)

Associations between the number of children, age at childbirths and prevalence of chronic low back pain: the Nord-Trøndelag Health Study
por: Heuch, Ingrid, et al.
Publicado: (2020)

Does the risk of chronic low back pain depend on age at menarche or menopause? A population-based cross-sectional and cohort study: the Trøndelag Health Study
por: Heuch, Ingrid, et al.
Publicado: (2022)

Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study
por: Heuch, Ingrid, et al.
Publicado: (2023)

Estimates of success in patients with sciatica due to lumbar disc herniation depend upon outcome measure
por: Haugen, Anne Julsrud, et al.
Publicado: (2011)

Prognostic factors for non-success in patients with sciatica and disc herniation
por: Haugen, Anne Julsrud, et al.
Publicado: (2012)

Transcriptional Profiling of mRNAs and microRNAs in Human Bone Marrow Precursor B Cells Identifies Subset- and Age-Specific Variations
por: Jensen, Kristin, et al.
Publicado: (2013)

Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population
por: Jensen, Tue S, et al.
Publicado: (2009)

Follow-up score, change score or percentage change score for determining clinical important outcome following surgery? An observational study from the Norwegian registry for Spine surgery evaluating patient reported outcome measures in lumbar spinal stenosis and lumbar degenerative spondylolisthesis
por: Austevoll, Ivar Magne, et al.
Publicado: (2019)

Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: a population based cohort study (The HUNT Study)
por: Johnsen, Marianne Bakke, et al.
Publicado: (2016)

Effect of Modic Changes in Cervical Degenerative Disease
por: Kang, Kyung Tag, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g0pg6um7lh8udvj01l9rmkducf