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Report of an Experiment With a Fetal Ex-Utero Support System in Piglets
Extreme prematurity remains one of the leading causes of neonatal death. An ex-utero treatment strategy that allows the fetus to develop beyond this period until capable of tolerating the transition to post-natal physiology would significantly impact the quality of care offered for this pre-viable p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224797/ https://www.ncbi.nlm.nih.gov/pubmed/37252594 http://dx.doi.org/10.7759/cureus.38223 |
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author | Abrao Trad, Ayssa T Buddington, Randal Enninga, Elizabeth Duncan, Jose Schenone, Claudio V Mari, Giancarlo Buddington, Karyl Schenone, Mauro |
author_facet | Abrao Trad, Ayssa T Buddington, Randal Enninga, Elizabeth Duncan, Jose Schenone, Claudio V Mari, Giancarlo Buddington, Karyl Schenone, Mauro |
author_sort | Abrao Trad, Ayssa T |
collection | PubMed |
description | Extreme prematurity remains one of the leading causes of neonatal death. An ex-utero treatment strategy that allows the fetus to develop beyond this period until capable of tolerating the transition to post-natal physiology would significantly impact the quality of care offered for this pre-viable patient population. In this study, we report our experience with an ex-utero support system for fetal pigs with the goal of support and survival for eight hours. Our experiment included two pigs at a gestational age equivalent to a 32-week human fetus. Following ultrasound assessment and delivery via hysterotomy, the fetuses were transferred to a 40 L glass aquarium filled with warmed lactated Ringer's solution and connected to an arteriovenous (AV) circuit that included a centrifugal pump and a pediatric oxygenator. Fetus 1 was successfully cannulated and survived for seven hours (expected maximum duration of eight hours). Fetus 2 died shortly after hysterotomy, secondary to failure at the cannulation stage. Our results suggest that ex-utero support of the premature fetal pig is feasible, contributing to a scarce body of evidence. However, further studies are needed before effectively translating an artificial placenta system into the clinical arena. |
format | Online Article Text |
id | pubmed-10224797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-102247972023-05-29 Report of an Experiment With a Fetal Ex-Utero Support System in Piglets Abrao Trad, Ayssa T Buddington, Randal Enninga, Elizabeth Duncan, Jose Schenone, Claudio V Mari, Giancarlo Buddington, Karyl Schenone, Mauro Cureus Obstetrics/Gynecology Extreme prematurity remains one of the leading causes of neonatal death. An ex-utero treatment strategy that allows the fetus to develop beyond this period until capable of tolerating the transition to post-natal physiology would significantly impact the quality of care offered for this pre-viable patient population. In this study, we report our experience with an ex-utero support system for fetal pigs with the goal of support and survival for eight hours. Our experiment included two pigs at a gestational age equivalent to a 32-week human fetus. Following ultrasound assessment and delivery via hysterotomy, the fetuses were transferred to a 40 L glass aquarium filled with warmed lactated Ringer's solution and connected to an arteriovenous (AV) circuit that included a centrifugal pump and a pediatric oxygenator. Fetus 1 was successfully cannulated and survived for seven hours (expected maximum duration of eight hours). Fetus 2 died shortly after hysterotomy, secondary to failure at the cannulation stage. Our results suggest that ex-utero support of the premature fetal pig is feasible, contributing to a scarce body of evidence. However, further studies are needed before effectively translating an artificial placenta system into the clinical arena. Cureus 2023-04-27 /pmc/articles/PMC10224797/ /pubmed/37252594 http://dx.doi.org/10.7759/cureus.38223 Text en Copyright © 2023, Abrao Trad et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Obstetrics/Gynecology Abrao Trad, Ayssa T Buddington, Randal Enninga, Elizabeth Duncan, Jose Schenone, Claudio V Mari, Giancarlo Buddington, Karyl Schenone, Mauro Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title | Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title_full | Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title_fullStr | Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title_full_unstemmed | Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title_short | Report of an Experiment With a Fetal Ex-Utero Support System in Piglets |
title_sort | report of an experiment with a fetal ex-utero support system in piglets |
topic | Obstetrics/Gynecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224797/ https://www.ncbi.nlm.nih.gov/pubmed/37252594 http://dx.doi.org/10.7759/cureus.38223 |
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