Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients remains dismal. The cellular differentiation states underlyin...

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Detalles Bibliográficos
Autores principales: DeMartino, Jeff, Meister, Michael T., Visser, Lindy L., Brok, Mariël, Groot Koerkamp, Marian J. A., Wezenaar, Amber K. L., Hiemcke-Jiwa, Laura S., de Souza, Terezinha, Merks, Johannes H. M., Rios, Anne C., Holstege, Frank C. P., Margaritis, Thanasis, Drost, Jarno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224926/
https://www.ncbi.nlm.nih.gov/pubmed/37244912
http://dx.doi.org/10.1038/s41467-023-38886-8

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