Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans

The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity’s in placebo responders versus non-responders. We dis...

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Autores principales: Crawford, Lewis S., Meylakh, Noemi, Macey, Paul M., Macefield, Vaughan G., Keay, Kevin A., Henderson, Luke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224990/
https://www.ncbi.nlm.nih.gov/pubmed/37244947
http://dx.doi.org/10.1038/s42003-023-04951-7
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author Crawford, Lewis S.
Meylakh, Noemi
Macey, Paul M.
Macefield, Vaughan G.
Keay, Kevin A.
Henderson, Luke A.
author_facet Crawford, Lewis S.
Meylakh, Noemi
Macey, Paul M.
Macefield, Vaughan G.
Keay, Kevin A.
Henderson, Luke A.
author_sort Crawford, Lewis S.
collection PubMed
description The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity’s in placebo responders versus non-responders. We distinguish stimulus-independent and stimulus-dependent neural networks that display altered connections between the hypothalamus, anterior cingulate cortex and midbrain periaqueductal gray matter. This dual regulatory system underpins an individual’s ability to mount placebo analgesia.
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spelling pubmed-102249902023-05-29 Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans Crawford, Lewis S. Meylakh, Noemi Macey, Paul M. Macefield, Vaughan G. Keay, Kevin A. Henderson, Luke A. Commun Biol Article The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity’s in placebo responders versus non-responders. We distinguish stimulus-independent and stimulus-dependent neural networks that display altered connections between the hypothalamus, anterior cingulate cortex and midbrain periaqueductal gray matter. This dual regulatory system underpins an individual’s ability to mount placebo analgesia. Nature Publishing Group UK 2023-05-27 /pmc/articles/PMC10224990/ /pubmed/37244947 http://dx.doi.org/10.1038/s42003-023-04951-7 Text en © Crown 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Crawford, Lewis S.
Meylakh, Noemi
Macey, Paul M.
Macefield, Vaughan G.
Keay, Kevin A.
Henderson, Luke A.
Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title_full Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title_fullStr Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title_full_unstemmed Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title_short Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
title_sort stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224990/
https://www.ncbi.nlm.nih.gov/pubmed/37244947
http://dx.doi.org/10.1038/s42003-023-04951-7
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