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Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States

PURPOSE: Identifying patients with bipolar disorder (BD) in manic states (BD-M) who are at a high risk of physical violence is a matter of clinical concern. This retrospective institution-based study aimed to identify simple, rapid, and inexpensive clinical markers of physical violence in patients w...

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Autores principales: Li, Xuelong, Gao, Yakun, Liu, Yiyi, Wang, Ying, Wu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225141/
https://www.ncbi.nlm.nih.gov/pubmed/37250432
http://dx.doi.org/10.2147/RMHP.S403170
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author Li, Xuelong
Gao, Yakun
Liu, Yiyi
Wang, Ying
Wu, Qing
author_facet Li, Xuelong
Gao, Yakun
Liu, Yiyi
Wang, Ying
Wu, Qing
author_sort Li, Xuelong
collection PubMed
description PURPOSE: Identifying patients with bipolar disorder (BD) in manic states (BD-M) who are at a high risk of physical violence is a matter of clinical concern. This retrospective institution-based study aimed to identify simple, rapid, and inexpensive clinical markers of physical violence in patients with BD-M. PATIENTS AND METHODS: The anonymized sociodemographic variables (sex, age, years of education, marital status) and clinical ones (weight, height, body mass index, blood pressure, the score of BRMS, number of BD episodes, psychotic symptoms, history of violence, biochemical parameters, and blood routine parameters) of 316 BD-M participants were collected, and the risk of physical violence was identified using the Brøset Violence Checklist (BVC). Difference tests, correlation analyses, and multivariate linear regression analysis were performed to identify clinical markers for the risk of physical violence. RESULTS: The participants were categorized into groups at low (49, 15.51%), medium (129, 40.82%), and high (138, 43.67%) risk of physical violence. The number of BD episodes, serum uric acid (UA), free thyroxine (FT4) levels, history of violence, and monocyte-to-lymphocyte ratio (MLR) differed significantly between groups (all P<0.05). The number of BD episodes (r=0.152), FT3 (r=0.131) and FT4 (r=0.132) levels, history of violence (r=0.206), and MLR (r=−0.132) were significantly correlated with the risk of physical violence (all P<0.05). The existence of history of violence, number of BD episodes, UA, FT4, and MLR were identified as clinical markers of the risk of physical violence in patients with BD-M (all P<0.05). CONCLUSION: These identified markers are readily available at initial presentation and may help in the timely assessment and treatment of patients with BD-M.
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spelling pubmed-102251412023-05-29 Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States Li, Xuelong Gao, Yakun Liu, Yiyi Wang, Ying Wu, Qing Risk Manag Healthc Policy Original Research PURPOSE: Identifying patients with bipolar disorder (BD) in manic states (BD-M) who are at a high risk of physical violence is a matter of clinical concern. This retrospective institution-based study aimed to identify simple, rapid, and inexpensive clinical markers of physical violence in patients with BD-M. PATIENTS AND METHODS: The anonymized sociodemographic variables (sex, age, years of education, marital status) and clinical ones (weight, height, body mass index, blood pressure, the score of BRMS, number of BD episodes, psychotic symptoms, history of violence, biochemical parameters, and blood routine parameters) of 316 BD-M participants were collected, and the risk of physical violence was identified using the Brøset Violence Checklist (BVC). Difference tests, correlation analyses, and multivariate linear regression analysis were performed to identify clinical markers for the risk of physical violence. RESULTS: The participants were categorized into groups at low (49, 15.51%), medium (129, 40.82%), and high (138, 43.67%) risk of physical violence. The number of BD episodes, serum uric acid (UA), free thyroxine (FT4) levels, history of violence, and monocyte-to-lymphocyte ratio (MLR) differed significantly between groups (all P<0.05). The number of BD episodes (r=0.152), FT3 (r=0.131) and FT4 (r=0.132) levels, history of violence (r=0.206), and MLR (r=−0.132) were significantly correlated with the risk of physical violence (all P<0.05). The existence of history of violence, number of BD episodes, UA, FT4, and MLR were identified as clinical markers of the risk of physical violence in patients with BD-M (all P<0.05). CONCLUSION: These identified markers are readily available at initial presentation and may help in the timely assessment and treatment of patients with BD-M. Dove 2023-05-24 /pmc/articles/PMC10225141/ /pubmed/37250432 http://dx.doi.org/10.2147/RMHP.S403170 Text en © 2023 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Xuelong
Gao, Yakun
Liu, Yiyi
Wang, Ying
Wu, Qing
Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title_full Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title_fullStr Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title_full_unstemmed Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title_short Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States
title_sort clinical markers of physical violence in patients with bipolar disorder in manic states
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225141/
https://www.ncbi.nlm.nih.gov/pubmed/37250432
http://dx.doi.org/10.2147/RMHP.S403170
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