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Insights into the Role of Inflammation in the Management of Atherosclerosis

Atherosclerosis is the biological basis of ischemic heart disease and ischemic stroke, the leading causes of death in the world. After decades of studies, the understanding of atherosclerosis has evolved dramatically, and inflammation has been recognized as one of the most relevant pillars in all ph...

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Autores principales: Rocha, Viviane Zorzanelli, Rached, Fabiana Hanna, Miname, Marcio Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225146/
https://www.ncbi.nlm.nih.gov/pubmed/37250107
http://dx.doi.org/10.2147/JIR.S276982
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author Rocha, Viviane Zorzanelli
Rached, Fabiana Hanna
Miname, Marcio Hiroshi
author_facet Rocha, Viviane Zorzanelli
Rached, Fabiana Hanna
Miname, Marcio Hiroshi
author_sort Rocha, Viviane Zorzanelli
collection PubMed
description Atherosclerosis is the biological basis of ischemic heart disease and ischemic stroke, the leading causes of death in the world. After decades of studies, the understanding of atherosclerosis has evolved dramatically, and inflammation has been recognized as one of the most relevant pillars in all phases of atherosclerotic disease. Nevertheless, only recently, the trial CANTOS, and subsequent outcome studies with colchicine, finally provided proof-of-concept evidence that anti-inflammatory therapies were able to reduce cardiovascular events with no influence on lipid levels. These landmark studies inaugurated an era of clinical and pre-clinical studies of immunomodulatory strategies focused on reduction of cardiovascular risk. Although there are promising results in the field, selection of the most appropriate immunomodulatory therapy and identification of patients who could benefit the most, are still enormous challenges. Further research is imperative before we can finally advance towards regular use of anti-inflammatory agents to reduce atherosclerotic events in our clinical practice.
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spelling pubmed-102251462023-05-29 Insights into the Role of Inflammation in the Management of Atherosclerosis Rocha, Viviane Zorzanelli Rached, Fabiana Hanna Miname, Marcio Hiroshi J Inflamm Res Review Atherosclerosis is the biological basis of ischemic heart disease and ischemic stroke, the leading causes of death in the world. After decades of studies, the understanding of atherosclerosis has evolved dramatically, and inflammation has been recognized as one of the most relevant pillars in all phases of atherosclerotic disease. Nevertheless, only recently, the trial CANTOS, and subsequent outcome studies with colchicine, finally provided proof-of-concept evidence that anti-inflammatory therapies were able to reduce cardiovascular events with no influence on lipid levels. These landmark studies inaugurated an era of clinical and pre-clinical studies of immunomodulatory strategies focused on reduction of cardiovascular risk. Although there are promising results in the field, selection of the most appropriate immunomodulatory therapy and identification of patients who could benefit the most, are still enormous challenges. Further research is imperative before we can finally advance towards regular use of anti-inflammatory agents to reduce atherosclerotic events in our clinical practice. Dove 2023-05-24 /pmc/articles/PMC10225146/ /pubmed/37250107 http://dx.doi.org/10.2147/JIR.S276982 Text en © 2023 Rocha et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Rocha, Viviane Zorzanelli
Rached, Fabiana Hanna
Miname, Marcio Hiroshi
Insights into the Role of Inflammation in the Management of Atherosclerosis
title Insights into the Role of Inflammation in the Management of Atherosclerosis
title_full Insights into the Role of Inflammation in the Management of Atherosclerosis
title_fullStr Insights into the Role of Inflammation in the Management of Atherosclerosis
title_full_unstemmed Insights into the Role of Inflammation in the Management of Atherosclerosis
title_short Insights into the Role of Inflammation in the Management of Atherosclerosis
title_sort insights into the role of inflammation in the management of atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225146/
https://www.ncbi.nlm.nih.gov/pubmed/37250107
http://dx.doi.org/10.2147/JIR.S276982
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