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Main causes of death in advanced biliary tract cancer
BACKGROUND: There are no previous reports on the main causes of death in biliary tract cancer (BTC) patients. This study aimed to evaluate the main causes of death and survival rates in patients with BTC. METHODS: We retrospectively evaluated 143 patients who were diagnosed with unresectable BTC bet...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225207/ https://www.ncbi.nlm.nih.gov/pubmed/36991582 http://dx.doi.org/10.1002/cam4.5794 |
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author | Kimura‐Seto, Kana Kojima, Yasushi Komori, Shiori Hisada, Yuya Otake, Yuki Yanai, Yuka Saito, Akiko Akazawa, Naoki Tanaka, Yasuo Yokoi, Chizu Yanase, Mikio Akiyama, Junichi Yamamoto, Natsuyo Yamada, Kazuhiko |
author_facet | Kimura‐Seto, Kana Kojima, Yasushi Komori, Shiori Hisada, Yuya Otake, Yuki Yanai, Yuka Saito, Akiko Akazawa, Naoki Tanaka, Yasuo Yokoi, Chizu Yanase, Mikio Akiyama, Junichi Yamamoto, Natsuyo Yamada, Kazuhiko |
author_sort | Kimura‐Seto, Kana |
collection | PubMed |
description | BACKGROUND: There are no previous reports on the main causes of death in biliary tract cancer (BTC) patients. This study aimed to evaluate the main causes of death and survival rates in patients with BTC. METHODS: We retrospectively evaluated 143 patients who were diagnosed with unresectable BTC between August 2010 and March 2020. We classified the main causes of death based on laboratory data, imaging studies, and medical records. The main causes of death evaluated included liver failure, cholangitis, cachexia, other causes associated with tumor progression, and complications. We also analyzed survival rates for each main cause of death. RESULTS: After excluding patients who were lost to follow‐up, living patients, and patients who had no records of laboratory data within 30 days before the date of death, 108 patients were analyzed. The main cause of death was cholangitis in 33 (30.6%), cachexia in 22 (20.4%), liver failure in 10 (9.3%), other causes associated with tumor progression in 18 (16.7%), and complications in 25 (23.2%) patients. Median overall survival (OS) was 334.0 days in the chemotherapy group and 75.0 days in the best supportive care (BSC) group. Survival analyzed according to the main cause of death was significantly different between the chemotherapy and BSC groups; OS for cachexia, cholangitis, liver failure, other causes associated with tumor progression, and complications, respectively, were 453.0, 499.0, 567.0, 205.0, and 327.5 days (p = 0.003) in the chemotherapy group and 219.0, 69.0, 34.0, 93.0, and 56.0 days (p = 0.001) in the BSC group. CONCLUSION: The main causes of death in patients with advanced BTC are cholangitis, cachexia, liver failure, other causes associated with tumor progression, and complications. Other causes associated with tumor progression in the chemotherapy group, and liver failure in the BSC group as the main causes of death shortened the survival of BTC patients. |
format | Online Article Text |
id | pubmed-10225207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102252072023-05-29 Main causes of death in advanced biliary tract cancer Kimura‐Seto, Kana Kojima, Yasushi Komori, Shiori Hisada, Yuya Otake, Yuki Yanai, Yuka Saito, Akiko Akazawa, Naoki Tanaka, Yasuo Yokoi, Chizu Yanase, Mikio Akiyama, Junichi Yamamoto, Natsuyo Yamada, Kazuhiko Cancer Med RESEARCH ARTICLES BACKGROUND: There are no previous reports on the main causes of death in biliary tract cancer (BTC) patients. This study aimed to evaluate the main causes of death and survival rates in patients with BTC. METHODS: We retrospectively evaluated 143 patients who were diagnosed with unresectable BTC between August 2010 and March 2020. We classified the main causes of death based on laboratory data, imaging studies, and medical records. The main causes of death evaluated included liver failure, cholangitis, cachexia, other causes associated with tumor progression, and complications. We also analyzed survival rates for each main cause of death. RESULTS: After excluding patients who were lost to follow‐up, living patients, and patients who had no records of laboratory data within 30 days before the date of death, 108 patients were analyzed. The main cause of death was cholangitis in 33 (30.6%), cachexia in 22 (20.4%), liver failure in 10 (9.3%), other causes associated with tumor progression in 18 (16.7%), and complications in 25 (23.2%) patients. Median overall survival (OS) was 334.0 days in the chemotherapy group and 75.0 days in the best supportive care (BSC) group. Survival analyzed according to the main cause of death was significantly different between the chemotherapy and BSC groups; OS for cachexia, cholangitis, liver failure, other causes associated with tumor progression, and complications, respectively, were 453.0, 499.0, 567.0, 205.0, and 327.5 days (p = 0.003) in the chemotherapy group and 219.0, 69.0, 34.0, 93.0, and 56.0 days (p = 0.001) in the BSC group. CONCLUSION: The main causes of death in patients with advanced BTC are cholangitis, cachexia, liver failure, other causes associated with tumor progression, and complications. Other causes associated with tumor progression in the chemotherapy group, and liver failure in the BSC group as the main causes of death shortened the survival of BTC patients. John Wiley and Sons Inc. 2023-03-29 /pmc/articles/PMC10225207/ /pubmed/36991582 http://dx.doi.org/10.1002/cam4.5794 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Kimura‐Seto, Kana Kojima, Yasushi Komori, Shiori Hisada, Yuya Otake, Yuki Yanai, Yuka Saito, Akiko Akazawa, Naoki Tanaka, Yasuo Yokoi, Chizu Yanase, Mikio Akiyama, Junichi Yamamoto, Natsuyo Yamada, Kazuhiko Main causes of death in advanced biliary tract cancer |
title | Main causes of death in advanced biliary tract cancer |
title_full | Main causes of death in advanced biliary tract cancer |
title_fullStr | Main causes of death in advanced biliary tract cancer |
title_full_unstemmed | Main causes of death in advanced biliary tract cancer |
title_short | Main causes of death in advanced biliary tract cancer |
title_sort | main causes of death in advanced biliary tract cancer |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225207/ https://www.ncbi.nlm.nih.gov/pubmed/36991582 http://dx.doi.org/10.1002/cam4.5794 |
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