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Liraglutide-Induced Pancreatitis: A Case Report and Literature Review

Liraglutide is an anti-diabetic medication used for the treatment of type 2 diabetes mellitus, obesity, and chronic weight management. It is a glucagon-like peptide-1 (GLP-1) agonist that helps reduce postprandial hyperglycemia for up to 24 h after administration. It stimulates endogenous insulin se...

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Autores principales: Javed, Hamna, Kogilathota Jagirdhar, Gowthami Sai, Kashyap, Rahul, Vekaria, Pratikkumar H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225244/
https://www.ncbi.nlm.nih.gov/pubmed/37252522
http://dx.doi.org/10.7759/cureus.38263
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author Javed, Hamna
Kogilathota Jagirdhar, Gowthami Sai
Kashyap, Rahul
Vekaria, Pratikkumar H
author_facet Javed, Hamna
Kogilathota Jagirdhar, Gowthami Sai
Kashyap, Rahul
Vekaria, Pratikkumar H
author_sort Javed, Hamna
collection PubMed
description Liraglutide is an anti-diabetic medication used for the treatment of type 2 diabetes mellitus, obesity, and chronic weight management. It is a glucagon-like peptide-1 (GLP-1) agonist that helps reduce postprandial hyperglycemia for up to 24 h after administration. It stimulates endogenous insulin secretion according to glucose levels, and also delays gastric emptying and suppresses prandial glucagon secretion. Some of the common complications associated with liraglutide include hypoglycemia, headache, diarrhea, nausea, and vomiting. Uncommon adverse effects include pancreatitis, kidney failure, pancreatic cancer, and injection site reactions. In this article, we discussed a case of a 73-year-old male with a history of uncontrolled type 2 diabetes mellitus on long-term insulin and liraglutide who presented with abdominal pain, subjective fevers, dry heaves, tachycardia, and mildly reduced oxygen saturation. The patient was diagnosed with pancreatitis on the basis of laboratory and imaging findings. Liraglutide was discontinued, and the patient received supportive care with significant clinical improvement. The use of GLP-1 inhibitors has been increasing not only for diabetes mellitus management, but also for its promising effect on weight management. The literature review endorses our case report findings, and also discusses other complications of liraglutide. Therefore, we recommend to be cognizant of these side-effects upon starting liraglutide.
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spelling pubmed-102252442023-05-29 Liraglutide-Induced Pancreatitis: A Case Report and Literature Review Javed, Hamna Kogilathota Jagirdhar, Gowthami Sai Kashyap, Rahul Vekaria, Pratikkumar H Cureus Endocrinology/Diabetes/Metabolism Liraglutide is an anti-diabetic medication used for the treatment of type 2 diabetes mellitus, obesity, and chronic weight management. It is a glucagon-like peptide-1 (GLP-1) agonist that helps reduce postprandial hyperglycemia for up to 24 h after administration. It stimulates endogenous insulin secretion according to glucose levels, and also delays gastric emptying and suppresses prandial glucagon secretion. Some of the common complications associated with liraglutide include hypoglycemia, headache, diarrhea, nausea, and vomiting. Uncommon adverse effects include pancreatitis, kidney failure, pancreatic cancer, and injection site reactions. In this article, we discussed a case of a 73-year-old male with a history of uncontrolled type 2 diabetes mellitus on long-term insulin and liraglutide who presented with abdominal pain, subjective fevers, dry heaves, tachycardia, and mildly reduced oxygen saturation. The patient was diagnosed with pancreatitis on the basis of laboratory and imaging findings. Liraglutide was discontinued, and the patient received supportive care with significant clinical improvement. The use of GLP-1 inhibitors has been increasing not only for diabetes mellitus management, but also for its promising effect on weight management. The literature review endorses our case report findings, and also discusses other complications of liraglutide. Therefore, we recommend to be cognizant of these side-effects upon starting liraglutide. Cureus 2023-04-28 /pmc/articles/PMC10225244/ /pubmed/37252522 http://dx.doi.org/10.7759/cureus.38263 Text en Copyright © 2023, Javed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Javed, Hamna
Kogilathota Jagirdhar, Gowthami Sai
Kashyap, Rahul
Vekaria, Pratikkumar H
Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title_full Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title_fullStr Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title_full_unstemmed Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title_short Liraglutide-Induced Pancreatitis: A Case Report and Literature Review
title_sort liraglutide-induced pancreatitis: a case report and literature review
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225244/
https://www.ncbi.nlm.nih.gov/pubmed/37252522
http://dx.doi.org/10.7759/cureus.38263
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