Cargando…
Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis
BACKGROUND: The association between disease activity and erectile dysfunction (ED) in patients with inflammatory bowel disease (IBD) is inconsistent, although IBD, including ulcerative colitis (UC), is reported as a risk factor for ED. AIM: The purpose of this study was to explore this association i...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225469/ https://www.ncbi.nlm.nih.gov/pubmed/37256220 http://dx.doi.org/10.1093/sexmed/qfad024 |
_version_ | 1785050380576489472 |
---|---|
author | Furukawa, Shinya Takeshita, Eiji Miyake, Teruki Tange, Kazuhiro Tomida, Hideomi Yamamoto, Yasunori Ikeda, Yoshio Hiasa, Yoichi |
author_facet | Furukawa, Shinya Takeshita, Eiji Miyake, Teruki Tange, Kazuhiro Tomida, Hideomi Yamamoto, Yasunori Ikeda, Yoshio Hiasa, Yoichi |
author_sort | Furukawa, Shinya |
collection | PubMed |
description | BACKGROUND: The association between disease activity and erectile dysfunction (ED) in patients with inflammatory bowel disease (IBD) is inconsistent, although IBD, including ulcerative colitis (UC), is reported as a risk factor for ED. AIM: The purpose of this study was to explore this association in Japanese patients with UC. METHODS: In this study, we enrolled 165 Japanese male patients with UC. Information regarding the Sexual Health Inventory for Men (SHIM) score, medication, and severity of UC was obtained from medical records, self-administered questionnaires, and reports from physicians. The definition of ED and severe ED is a SHIM score <17 and <8, respectively. OUTCOMES: No association between severity of UC and ED was found in Japanese patients. Aging is independently positively associated with ED in patients with UC. RESULTS: The prevalence of severe ED and ED was 47.9% and 64.9%, respectively. In this study, mucosal healing, clinical remission, duration of UC, disease extent, and medication were not associated with the prevalence of ED. Older age (≥63 years of age) was independently positively associated with ED (adjusted odds ratio, 12.93; 95% CI: 4.51-43.00) and severe ED (adjusted odds ratio, 9.02; 95% CI: 3.66-23.91). CLINICAL IMPLICATIONS: Disease severity of UC might not be associated with the prevalence of ED in patients with UC. STRENGTHS AND LIMITATIONS: This is the first study to investigate the association between several factors regarding UC activity and ED. The limitation of this study is the definition of ED based on SHIM scores. CONCLUSION: No association between severity of UC and ED was found in Japanese patients. As expected, aging may be independently positively associated with ED in patients with UC. |
format | Online Article Text |
id | pubmed-10225469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102254692023-05-30 Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis Furukawa, Shinya Takeshita, Eiji Miyake, Teruki Tange, Kazuhiro Tomida, Hideomi Yamamoto, Yasunori Ikeda, Yoshio Hiasa, Yoichi Sex Med Original Research BACKGROUND: The association between disease activity and erectile dysfunction (ED) in patients with inflammatory bowel disease (IBD) is inconsistent, although IBD, including ulcerative colitis (UC), is reported as a risk factor for ED. AIM: The purpose of this study was to explore this association in Japanese patients with UC. METHODS: In this study, we enrolled 165 Japanese male patients with UC. Information regarding the Sexual Health Inventory for Men (SHIM) score, medication, and severity of UC was obtained from medical records, self-administered questionnaires, and reports from physicians. The definition of ED and severe ED is a SHIM score <17 and <8, respectively. OUTCOMES: No association between severity of UC and ED was found in Japanese patients. Aging is independently positively associated with ED in patients with UC. RESULTS: The prevalence of severe ED and ED was 47.9% and 64.9%, respectively. In this study, mucosal healing, clinical remission, duration of UC, disease extent, and medication were not associated with the prevalence of ED. Older age (≥63 years of age) was independently positively associated with ED (adjusted odds ratio, 12.93; 95% CI: 4.51-43.00) and severe ED (adjusted odds ratio, 9.02; 95% CI: 3.66-23.91). CLINICAL IMPLICATIONS: Disease severity of UC might not be associated with the prevalence of ED in patients with UC. STRENGTHS AND LIMITATIONS: This is the first study to investigate the association between several factors regarding UC activity and ED. The limitation of this study is the definition of ED based on SHIM scores. CONCLUSION: No association between severity of UC and ED was found in Japanese patients. As expected, aging may be independently positively associated with ED in patients with UC. Oxford University Press 2023-05-26 /pmc/articles/PMC10225469/ /pubmed/37256220 http://dx.doi.org/10.1093/sexmed/qfad024 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The International Society of Sexual Medicine https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Furukawa, Shinya Takeshita, Eiji Miyake, Teruki Tange, Kazuhiro Tomida, Hideomi Yamamoto, Yasunori Ikeda, Yoshio Hiasa, Yoichi Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title | Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title_full | Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title_fullStr | Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title_full_unstemmed | Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title_short | Disease activity and erectile dysfunction in Japanese patients with ulcerative colitis |
title_sort | disease activity and erectile dysfunction in japanese patients with ulcerative colitis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225469/ https://www.ncbi.nlm.nih.gov/pubmed/37256220 http://dx.doi.org/10.1093/sexmed/qfad024 |
work_keys_str_mv | AT furukawashinya diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT takeshitaeiji diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT miyaketeruki diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT tangekazuhiro diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT tomidahideomi diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT yamamotoyasunori diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT ikedayoshio diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis AT hiasayoichi diseaseactivityanderectiledysfunctioninjapanesepatientswithulcerativecolitis |