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A quinazoline derivative suppresses B cell hyper-activation and ameliorates the severity of systemic lupus erythematosus in mice

Background: Aberrant autoreactive B cell responses contribute to the pathogenesis of systemic lupus erythematosus (SLE). Currently, there is no safe and effective drug for intervention of SLE. Quinazoline derivative (N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, QNZ) is a NF-κB inhibitor and has p...

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Detalles Bibliográficos
Autores principales:	Zhang, Gan, Yang, Fan, Li, Juan, Chen, Shan, Kong, Yuhang, Mo, Chunfen, Leng, Xiao, Liu, Yang, Xu, Ying, Wang, Yantang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225574/ https://www.ncbi.nlm.nih.gov/pubmed/37256224 http://dx.doi.org/10.3389/fphar.2023.1159075

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