Cargando…

Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure

The prevalence of mitral (MR) and tricuspid regurgitation (TR), especially in heart failure (HF) populations, is high. However, the distinct role of atrioventricular valve diseases in HF, whether they are merely indicators of disease status or rather independent contributors in a vicious disease cyc...

Descripción completa

Detalles Bibliográficos
Autores principales: Curio, Jonathan, Beneduce, Alessandro, Giannini, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225583/
https://www.ncbi.nlm.nih.gov/pubmed/37255703
http://dx.doi.org/10.3389/fcvm.2023.1091309
_version_ 1785050405540986880
author Curio, Jonathan
Beneduce, Alessandro
Giannini, Francesco
author_facet Curio, Jonathan
Beneduce, Alessandro
Giannini, Francesco
author_sort Curio, Jonathan
collection PubMed
description The prevalence of mitral (MR) and tricuspid regurgitation (TR), especially in heart failure (HF) populations, is high. However, the distinct role of atrioventricular valve diseases in HF, whether they are merely indicators of disease status or rather independent contributors in a vicious disease cycle, is still not fully understood. For decades, tricuspid regurgitation (TR) was considered an innocent bystander subsequent to other heart or lung pathologies, thus, not needing dedicated treatment. Recent increasing awareness towards the role of atrioventricular valve diseases has revealed that MR and TR are, in fact, independent predictors of outcome in HF, thus, warranting attention in the HF treatment algorithm. This awareness arose, especially, with the development of minimally invasive transcatheter solutions providing new treatment options, which can also be used for patients considered as having increased surgical risk. However, outcomes of such transcatheter treatments have, in part, been sub-optimal and likely influenced by the status of the concomitant HF disease. Thus, this review aims to summarize data on the current understanding regarding the role of MR and TR in HF, how HF impacts outcomes of transcatheter MR and TR interventions, and how the understanding of this relationship might help to identify patients that benefit most from these therapies, which have proven to be lifesaving in properly selected candidates.
format Online
Article
Text
id pubmed-10225583
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102255832023-05-30 Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure Curio, Jonathan Beneduce, Alessandro Giannini, Francesco Front Cardiovasc Med Cardiovascular Medicine The prevalence of mitral (MR) and tricuspid regurgitation (TR), especially in heart failure (HF) populations, is high. However, the distinct role of atrioventricular valve diseases in HF, whether they are merely indicators of disease status or rather independent contributors in a vicious disease cycle, is still not fully understood. For decades, tricuspid regurgitation (TR) was considered an innocent bystander subsequent to other heart or lung pathologies, thus, not needing dedicated treatment. Recent increasing awareness towards the role of atrioventricular valve diseases has revealed that MR and TR are, in fact, independent predictors of outcome in HF, thus, warranting attention in the HF treatment algorithm. This awareness arose, especially, with the development of minimally invasive transcatheter solutions providing new treatment options, which can also be used for patients considered as having increased surgical risk. However, outcomes of such transcatheter treatments have, in part, been sub-optimal and likely influenced by the status of the concomitant HF disease. Thus, this review aims to summarize data on the current understanding regarding the role of MR and TR in HF, how HF impacts outcomes of transcatheter MR and TR interventions, and how the understanding of this relationship might help to identify patients that benefit most from these therapies, which have proven to be lifesaving in properly selected candidates. Frontiers Media S.A. 2023-05-15 /pmc/articles/PMC10225583/ /pubmed/37255703 http://dx.doi.org/10.3389/fcvm.2023.1091309 Text en © 2023 Curio, Beneduce and Giannini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Curio, Jonathan
Beneduce, Alessandro
Giannini, Francesco
Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title_full Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title_fullStr Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title_full_unstemmed Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title_short Transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
title_sort transcatheter mitral and tricuspid interventions—the bigger picture: valvular disease as part of heart failure
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225583/
https://www.ncbi.nlm.nih.gov/pubmed/37255703
http://dx.doi.org/10.3389/fcvm.2023.1091309
work_keys_str_mv AT curiojonathan transcathetermitralandtricuspidinterventionsthebiggerpicturevalvulardiseaseaspartofheartfailure
AT beneducealessandro transcathetermitralandtricuspidinterventionsthebiggerpicturevalvulardiseaseaspartofheartfailure
AT gianninifrancesco transcathetermitralandtricuspidinterventionsthebiggerpicturevalvulardiseaseaspartofheartfailure