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Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36
Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the face of inflammation-induced cartilage and bone damage, RA treatment remains insufficient. While research evidence indicates that acupuncture can exert anti-inflammatory and analgesic effects, improve the jo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225595/ https://www.ncbi.nlm.nih.gov/pubmed/37256145 http://dx.doi.org/10.3389/fimmu.2023.1164157 |
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author | Zhang, Yue Wang, Hui Gong, Yi-Nan Yang, Fu-Ming Wang, Shen-Jun Liu, Yang-Yang Gui, Yong-Qing Xie, Fei Xu, Zhi-Fang Guo, Yi |
author_facet | Zhang, Yue Wang, Hui Gong, Yi-Nan Yang, Fu-Ming Wang, Shen-Jun Liu, Yang-Yang Gui, Yong-Qing Xie, Fei Xu, Zhi-Fang Guo, Yi |
author_sort | Zhang, Yue |
collection | PubMed |
description | Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the face of inflammation-induced cartilage and bone damage, RA treatment remains insufficient. While research evidence indicates that acupuncture can exert anti-inflammatory and analgesic effects, improve the joint function of RA patients, and delay the disease, data on whether it can promote RA repair are lacking. Findings from the present work demonstrated that both the antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA) models can simulate joint swelling of RA. The AIA model was more stable than the CIA model, with a higher incidence of successful arthritis modeling. Moreover, the AIA mice model could simulate the signal molecules and related pathological processes of the autoimmune response in RA, as well as major pathways related to RA and antigen immune response mechanisms. Manual acupuncture (MA) at Zusanli (ST36) significantly improved paw redness and swelling, pain, and inflammatory cell infiltration in the joints in AIA mice. The therapeutic effect of MA on AIA is achieved primarily through the regulation of steroid hormone biosynthesis, cell metabolism, and tissue repair processes. MA at ST36 can increase the gene contents of tissue repair growth factors, including PEG3, GADD45A, GDF5, FGF5, SOX2, and ATP6V1C2 in the inflammatory side joints of AIA mice, as well as the gene expression of the anti-inflammatory cytokine IL-10. In conclusion, acupuncture may alleviate RA in the joints via modulating the tissue healing process. |
format | Online Article Text |
id | pubmed-10225595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102255952023-05-30 Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 Zhang, Yue Wang, Hui Gong, Yi-Nan Yang, Fu-Ming Wang, Shen-Jun Liu, Yang-Yang Gui, Yong-Qing Xie, Fei Xu, Zhi-Fang Guo, Yi Front Immunol Immunology Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the face of inflammation-induced cartilage and bone damage, RA treatment remains insufficient. While research evidence indicates that acupuncture can exert anti-inflammatory and analgesic effects, improve the joint function of RA patients, and delay the disease, data on whether it can promote RA repair are lacking. Findings from the present work demonstrated that both the antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA) models can simulate joint swelling of RA. The AIA model was more stable than the CIA model, with a higher incidence of successful arthritis modeling. Moreover, the AIA mice model could simulate the signal molecules and related pathological processes of the autoimmune response in RA, as well as major pathways related to RA and antigen immune response mechanisms. Manual acupuncture (MA) at Zusanli (ST36) significantly improved paw redness and swelling, pain, and inflammatory cell infiltration in the joints in AIA mice. The therapeutic effect of MA on AIA is achieved primarily through the regulation of steroid hormone biosynthesis, cell metabolism, and tissue repair processes. MA at ST36 can increase the gene contents of tissue repair growth factors, including PEG3, GADD45A, GDF5, FGF5, SOX2, and ATP6V1C2 in the inflammatory side joints of AIA mice, as well as the gene expression of the anti-inflammatory cytokine IL-10. In conclusion, acupuncture may alleviate RA in the joints via modulating the tissue healing process. Frontiers Media S.A. 2023-05-15 /pmc/articles/PMC10225595/ /pubmed/37256145 http://dx.doi.org/10.3389/fimmu.2023.1164157 Text en Copyright © 2023 Zhang, Wang, Gong, Yang, Wang, Liu, Gui, Xie, Xu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Yue Wang, Hui Gong, Yi-Nan Yang, Fu-Ming Wang, Shen-Jun Liu, Yang-Yang Gui, Yong-Qing Xie, Fei Xu, Zhi-Fang Guo, Yi Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title | Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title_full | Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title_fullStr | Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title_full_unstemmed | Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title_short | Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36 |
title_sort | pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at st36 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225595/ https://www.ncbi.nlm.nih.gov/pubmed/37256145 http://dx.doi.org/10.3389/fimmu.2023.1164157 |
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