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Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery
Since its discovery six decades ago, the predatory bacterium Bdellovibrio bacteriovorus has sparked recent interest as a potential remedy to the antibiotic resistance crisis. Here we give a comprehensive historical overview from discovery to progressive developments in microscopy and molecular mecha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225642/ https://www.ncbi.nlm.nih.gov/pubmed/37256055 http://dx.doi.org/10.3389/fmicb.2023.1168709 |
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author | Lai, Ting F. Ford, Rhian M. Huwiler, Simona G. |
author_facet | Lai, Ting F. Ford, Rhian M. Huwiler, Simona G. |
author_sort | Lai, Ting F. |
collection | PubMed |
description | Since its discovery six decades ago, the predatory bacterium Bdellovibrio bacteriovorus has sparked recent interest as a potential remedy to the antibiotic resistance crisis. Here we give a comprehensive historical overview from discovery to progressive developments in microscopy and molecular mechanisms. Research on B. bacteriovorus has moved from curiosity to a new model organism, revealing over time more details on its physiology and fascinating predatory life cycle with the help of a variety of methods. Based on recent findings in cryo-electron tomography, we recapitulate on the intricate molecular details known in the predatory life cycle including how this predator searches for its prey bacterium, to how it attaches, grows, and divides all from within the prey cell. Finally, the newly developed B. bacteriovorus progeny leave the prey cell remnants in the exit phase. While we end with some unanswered questions remaining in the field, new imaging technologies and quantitative, systematic advances will likely help to unravel them in the next decades. |
format | Online Article Text |
id | pubmed-10225642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102256422023-05-30 Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery Lai, Ting F. Ford, Rhian M. Huwiler, Simona G. Front Microbiol Microbiology Since its discovery six decades ago, the predatory bacterium Bdellovibrio bacteriovorus has sparked recent interest as a potential remedy to the antibiotic resistance crisis. Here we give a comprehensive historical overview from discovery to progressive developments in microscopy and molecular mechanisms. Research on B. bacteriovorus has moved from curiosity to a new model organism, revealing over time more details on its physiology and fascinating predatory life cycle with the help of a variety of methods. Based on recent findings in cryo-electron tomography, we recapitulate on the intricate molecular details known in the predatory life cycle including how this predator searches for its prey bacterium, to how it attaches, grows, and divides all from within the prey cell. Finally, the newly developed B. bacteriovorus progeny leave the prey cell remnants in the exit phase. While we end with some unanswered questions remaining in the field, new imaging technologies and quantitative, systematic advances will likely help to unravel them in the next decades. Frontiers Media S.A. 2023-05-15 /pmc/articles/PMC10225642/ /pubmed/37256055 http://dx.doi.org/10.3389/fmicb.2023.1168709 Text en Copyright © 2023 Lai, Ford and Huwiler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Lai, Ting F. Ford, Rhian M. Huwiler, Simona G. Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title | Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title_full | Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title_fullStr | Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title_full_unstemmed | Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title_short | Advances in cellular and molecular predatory biology of Bdellovibrio bacteriovorus six decades after discovery |
title_sort | advances in cellular and molecular predatory biology of bdellovibrio bacteriovorus six decades after discovery |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225642/ https://www.ncbi.nlm.nih.gov/pubmed/37256055 http://dx.doi.org/10.3389/fmicb.2023.1168709 |
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